Role of the gut microbiota in pediatric hyperuricemia and advances in microbiota-targeted interventions

CHEN Xuechun; ZHOU Xuelian; FU Junfen

doi:10.11852/zgetbjzz2025-1016

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Chinese Journal of Child Health Care ›› 2026, Vol. 34 ›› Issue (11) : 1263-1268. DOI: 10.11852/zgetbjzz2025-1016

Review

Role of the gut microbiota in pediatric hyperuricemia and advances in microbiota-targeted interventions

CHEN Xuechun, ZHOU Xuelian, FU Junfen

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Abstract

With the rising prevalence of overweight and obesity among children and adolescents, the prevalence of hyperuricemia among children and adolescents has increased significantly. However, safe and effective treatments suitable for pediatric patients remain limited. Recent evidence suggests that the gut microbiota may be an important target for modulating uric acid metabolism. However, most available evidence comes from animal studies and the underlying mechanisms remain incompletely understood. Furthermore, clinical translation faces challenges related to strain safety, long-term efficacy, and practical feasibility. This review summarizes the potential mechanisms by which gut microbiota contribute to the development of pediatric hyperuricemia, with a focus on its roles in regulating purine metabolism, uric acid excretion and reabsorption, and inflammatory responses. In addition, existing microbiota-based interventions are reviewed, and their clinical prospects and limitations are discussed, aiming to provide a theoretical basis and research direction for developing safer and more precise therapeutic strategies for pediatric hyperuricemia.

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obesity / hyperuricemia / gut microbiota / children and adolescents

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CHEN Xuechun, ZHOU Xuelian, FU Junfen. Role of the gut microbiota in pediatric hyperuricemia and advances in microbiota-targeted interventions[J]. Chinese Journal of Child Health Care. 2026, 34(11): 1263-1268 https://doi.org/10.11852/zgetbjzz2025-1016

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