Multidimensional mechanisms of Chinese dyslexia from cognitive, neurobiological, and genetic perspectives

SONG Ranran; ZHANG Jiao

doi:10.11852/zgetbjzz2025-0902

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (9) : 939-943. DOI: 10.11852/zgetbjzz2025-0902

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Multidimensional mechanisms of Chinese dyslexia from cognitive, neurobiological, and genetic perspectives

SONG Ranran, ZHANG Jiao

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Abstract

This review summarizes recent advances in Chinese developmental dyslexia across cognitive functions, neurophysiological, and etiology.Phonological, morphological awareness, orthographic, and rapid automatized naming constitute core deficits in Chinese dyslexia.Chinese children with dyslexia exhibit reduced activation in the left inferior frontal gyrus and increased activation in the right precentral/middle temporal gyrus, suggesting impaired phonological processing and potential compensatory mechanisms.Genetic research has identified novel susceptibility genes (e.g., SEMA3F, AUTS2, EVC).Furthermore, significant roles of environmental factors and gene-environment interactions were explored.Further prospective studies are warranted to elucidate both the universal and specific cognitive functions, neurophysiological, and etiology underlying Chinese developmental dyslexia.

Key words

Chinese developmental dyslexia / cognitive functions / neurophysiology / genetic susceptibility / gene-environment interactions

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SONG Ranran, ZHANG Jiao. Multidimensional mechanisms of Chinese dyslexia from cognitive, neurobiological, and genetic perspectives[J]. Chinese Journal of Child Health Care. 2025, 33(9): 939-943 https://doi.org/10.11852/zgetbjzz2025-0902

References

[1] Peterson RL, Pennington BF.Developmental dyslexia[J].Lancet, 2012,379(9830): 1997-2007.
[2] Peterson RL, Pennington BF.Developmental dyslexia[J].Annu Rev Clin Psychol, 2015,11: 283-307.
[3] Liu L, Wang J, Shao S, et al.Descriptive epidemiology of prenatal and perinatal risk factors in a Chinese population with reading disorder[J].Sci Rep, 2016,6: 36697.
[4] Xiao P, Zhu K, Feng Y, et al.Associations between dyslexia and children′s mental health: Findings from a follow-up study in China[J].Psychiatry Res, 2023,324: 115188.
[5] Cheng C, Yao Y, Wang Z, et al.Visual attention span and phonological skills in Chinese developmental dyslexia[J].Res Dev Disabil, 2021,116: 104015.
[6] Jin Y, Zhao J, Su X, et al.A different finding on the role of cerebro-cerebellar RSFC in reading skills among Chinese children with developmental dyslexia[J].J Psychiatr Res, 2025,186: 192-199.
[7] Yang Y, Zuo Z, Tam F, et al.The brain basis of handwriting deficits in Chinese children with developmental dyslexia[J].Dev Sci, 2022,25(2): e13161.
[8] Zhao J, Song Z, Zhao Y, et al.White matter connectivity in uncinate fasciculus accounts for visual attention span in developmental dyslexia[J].Neuropsychologia, 2022,177: 108414.
[9] 黄爽, 刘芸, 张雅新, 等.汉语阅读障碍儿童语言认知能力缺陷特征分析[J].成都医学院学报, 2023,18(6): 774-777.
Huang S, Liu Y, Zhang YX, et al.Language cognitive deficits of Chinese dyslexic children[J].Journal of Chengdu Medical College, 2023,18(6): 774-777.(in Chinese)
[10] Wang L, Liu D, Kwan-Chen LL, et al.Lower prosodic sensitivity in Chinese children with dyslexia and its impact on Chinese reading[J].Dyslexia, 2022,28(3): 342-358.
[11] Chan K, Chung KKH, Lam CB.What are the cognitive-linguistic profiles and subtypes of Chinese adolescents with dyslexia?[J].Dyslexia, 2023,29(4): 369-384.
[12] 唐淑婷, 刘芳芳, 邓柯高, 等.汉语发展性阅读困难儿童复合词加工的事件相关电位研究[J].中国心理卫生杂志, 2022,36(4): 347-353.
Tang ST, Liu FF,Deng KG, et al.An event-related potential study of compound word processing in developmental dyslexic children in Chinese[J].Chinese Mental Health Journal, 2022,36(4): 347-353.(in Chinese)
[13] 张文静.亚词汇正字法、语音和语义加工在汉字识别中的相对重要性及任务调制效应[D].杭州: 杭州师范大学, 2024.
Zhang WJ.The predominance of sublexical orthographic, phonological, and semantic processing in Chinese character recognition and the modulation effect of task demands[D].Hangzhou: Hangzhou Normal University, 2024.(in Chinese)
[14] Zhang W, Liu T, Chen W, et al.Overreliance on sublexical phonological processing in visual word recognition for third-grade mandarin-speaking dyslexic children[J].Dyslexia, 2025,31(1): e1795.
[15] 张亚静, 陈刘昕, 林榕萍, 等.阅读障碍儿童句法意识、词汇知识和阅读流畅性加工缺陷研究[J].中国特殊教育, 2024,8: 62-70.
Zhang YJ, Chen LX, Lin RP, et al.Research on syntactic awareness, vocabulary knowledge, and reading fluency processing deficits in children with dyslexia[J].Chinese Journal of Special Education, 2024,8: 62-70.(in Chinese)
[16] Wang YK, Tong CK, Lui M, et al.Perceptual expertise with Chinese characters predicts Chinese reading performance among Hong Kong Chinese children with developmental dyslexia[J].PLoS One, 2021,16(1): e0243440.
[17] Yang X, Zhang J, Lv Y, et al.Failure of resting-state frontal-occipital connectivity in linking visual perception with reading fluency in Chinese children with developmental dyslexia[J].Neuroimage, 2021,233: 117911.
[18] Duan B, Tang X, Wang D, et al.Impaired processing of spatiotemporal visual attention engagement deficits in Chinese children with developmental dyslexia[J].J Vis 2024,24(13): 2.
[19] Tso RV, Chan RT, Chan Y, et al.Holistic processing of Chinese characters in college students with dyslexia[J].Sci Rep, 2021,11(1): 1973.
[20] Tang J, Ma X, Peng P, et al.Visual attention span deficit in developmental dyslexia: A Meta-analysis[J].Res Dev Disabil, 2023,141: 104590.
[21] Liu J, Ren X, Wang Y, et al.Visual attention span capacity in developmental dyslexia: A Meta-analysis[J].Res Dev Disabil, 2023,135: 104465.
[22] Siok WT, Tan LH.Is phonological deficit a necessary or sufficient condition for Chinese reading disability?[J].Brain Lang, 2022,226: 105069.
[23] 祝可, 张红霞, 王蕾, 等.发展性阅读障碍儿童中央执行功能缺陷研究[J].中国特殊教育, 2023,9: 54-62.
Ke Z, Zhang HX, Wang L, et al.A study of central executive function deficits in children with developmental dyslexia[J].Chinese Journal of Special Education, 2023,9: 54-62.(in Chinese)
[24] Ji L, Zhao Q, Gu H, et al.Effect of executive function on event-based prospective memory for different forms of learning disabilities[J].Front Psychol, 2021,12: 528883.
[25] Wang NY, Wang HS, Liu Y, et al.Investigating the white matter correlates of reading performance: Evidence from Chinese children with reading difficulties[J].PLoS One, 2021,16(3): e0248434.
[26] Yan X, Jiang K, Li H, et al.Convergent and divergent brain structural and functional abnormalities associated with developmental dyslexia[J].Elife, 2021,10:e69523.
[27] Zhao Y, Liu J, Ma X, et al.Microstructural lateralization of thalamocortical connections in individuals with a history of reading difficulties[J].Neuroimage, 2025,308: 121071.
[28] Li Y, Bi H.Comparative research on neural dysfunction in children with dyslexia under different writing systems: A Meta-analysis study[J].Neurosci Biobehav Rev, 2022,137: 104650.
[29] Wang A, Yan X, Feng G, et al.Shared and task-specific brain functional differences across multiple tasks in children with developmental dyslexia[J].Neuropsychologia, 2024,201: 108935.
[30] Liu Y, Qian Y, Bi H.Visual motion processing in Chinese children with developmental dyslexia: An fMRI study[J].Dyslexia, 2022,28(4): 431-447.
[31] Zhang L, Hu J, Liu X, et al.Disrupted subcortical-cortical connections in a phonological but not semantic task in Chinese children with dyslexia[J].Front Hum Neurosci, 2021,14: 611008.
[32] Tan S, Deng S, Song X, et al.Altered effective connectivity on rapid automatized naming deficits in Chinese children with developmental dyslexia: An rs-fMRI study with ganger causality analysis[J].J Psychiatr Res, 2024,175: 235-242.
[33] Xu X, Song X, Lin L, et al.White matter substrates underlying morphological awareness deficit in Chinese children with developmental dyslexia[J].J Psychiatr Res, 2024,134: 111083.
[34] Liu Z, Li J, Bi H, et al.Disruption of functional brain networks underlies the handwriting deficit in children with developmental dyslexia[J].Front Neurosci, 2022,16: 919440.
[35] Haworth CMA, Kovas Y, Harlaar N, et al.Generalist genes and learning disabilities:A multivariate genetic analysis of low performance in reading, mathematics, language and general cognitive ability in a sample of 8 000 12-year-old twins[J].J Child Psychol Psychiatry, 2009,50(10): 1318-1325.
[36] Shao S, Kong R, Zou L, et al.The roles of genes in the neuronal migration and neurite outgrowth network in developmental dyslexia: Single-and multiple-risk genetic variants[J].Mol Neurobiol, 2016,53(6): 3967-3975.
[37] Doust C, Fontanillas P, Eising E, et al.Discovery of 42 genome-wide significant loci associated with dyslexia[J].Nat Genet,2022,54(11): 1621-1629.
[38] Wang Z, Zhao S, Zhang L, et al.A genome-wide association study identifies a new variant associated with word reading fluency in Chinese children[J].Genes, Genes Brain Behav, 2023,22(1): e12833.
[39] 赵华, 刘瑞芳, 姚水洪, 等.KIAA0319基因与汉族儿童阅读障碍的关联性研究[J].听力学及言语疾病杂志, 2023,31(6): 522-526.
Zhao H, Liu RF, Yao SH, et al.KIAA0319 gene polymorphisms are associated with developmental dyslexia in han children[J].J Audiol Speech Pathol, 2023,31(6): 522-526.(in Chinese)
[40] Zhu K, Liu Q, Xie X, et al.Interaction between manganese and SLC6A3 genetic polymorphisms in relation to dyslexia[J].Neurotoxicology, 2022,92: 102-109.
[41] Zhu K, Liu Q, Xie X, et al.The combined effect between BDNF genetic polymorphisms and exposure to metals on the risk of Chinese dyslexia[J].Environ Pollut (barking, Essex : 1987), 2022,308: 119640.
[42] Liu Q, Zhu B, Xue Q, et al.The associations of zinc and GRIN2B genetic polymorphisms with the risk of dyslexia[J].Environ Res, 2020,191: 110207.
[43] Rosenberg J, Pennington BF, Willcutt EG, et al.Gene by environment interactions influencing reading disability and the inattentive symptom dimension of attention deficit/hyperactivity disorder[J].J Child Psychol Psychiatry, 2012,53(3): 243-251.
[44] Huang A, Zhang J, Wu K, et al.Exposure to multiple metals and the risk of dyslexia - a case control study in Shantou, China[J].Environ Pollut, 2022,307: 119518.
[45] Zhu K, Wan Y, Zhu B, et al.Exposure to organophosphate, pyrethroid, and neonicotinoid insecticides and dyslexia: Association with oxidative stress[J].Environ Pollut, 2024,344: 123362.
[46] Jiang Q, Wan Y, Zhu K, et al.Association of exposure to phthalates and phthalate alternatives with dyslexia in Chinese primary school children[J].Environ Sci Pollut Res Int, 2024,31(19): 28392-28403.
[47] Liu R, Wan Y, Zhu B, et al.Association between urinary BTEX metabolites and dyslexic odds among school-aged children[J].Environ Sci Pollut Res Int, 2024,31(21): 31443-31454.
[48] Wang H, Wan Y, Liu Q, et al.Association between urinary 2-hydroxyethyl mercapturic acid and dyslexia among school-aged children[J].Environ Sci Pollut Res Int, 2023,30(45): 101091-101098.
[49] Xiang Z, Wang H, Zhu K, et al.Phenol exposure, polygenic risk score, and dyslexia in Chinese children: Gene-environment interaction[J].Environ Pollut, 2025,379: 126536.
[50] Yang Y, Zheng T, Tang Q, et al.Developmental dyslexia genes are selectively targeted by diverse environmental pollutants[J].BMC Psychiatry, 2024,24(1): 509.