Identification and management of resistance to thyroid hormone syndrome

ZHANG Xingxing; LIAO Linying

doi:10.11852/zgetbjzz2025-0780

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (10) : 1056-1060. DOI: 10.11852/zgetbjzz2025-0780

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Identification and management of resistance to thyroid hormone syndrome

ZHANG Xingxing, LIAO Linying

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Abstract

Resistance to thyroid hormone (RTH) is a rare endocrine disorder caused by mutations in thyroid hormone receptors or abnormalities in thyroid hormone metabolism/transmission, characterized by decreased sensitivity to thyroid hormones in target tissues, elevated serum FT3/FT4 levels, and uncontrolled thyroid-stimulating hormone (TSH) production.RTH significantly impacts the development of various systems in children, presenting with highly heterogeneous clinical manifestations that are prone to misdiagnosis and missed diagnosis.This article focuses on the early identification, diagnosis, individualized treatment and long-term health management strategies of RTH based on the pathogenesis, aiming to provide reference for clinicians.

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resistance to thyroid hormone / gene diagnosis / individualized treatment / children

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ZHANG Xingxing, LIAO Linying. Identification and management of resistance to thyroid hormone syndrome[J]. Chinese Journal of Child Health Care. 2025, 33(10): 1056-1060 https://doi.org/10.11852/zgetbjzz2025-0780

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