Diagnostic value of peripheral blood biomarkers in neurodevelopmental disorders

ZHAO Tingjiao; WEI Hua

doi:10.11852/zgetbjzz2025-0775

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Chinese Journal of Child Health Care ›› 2026, Vol. 34 ›› Issue (5) : 561-565. DOI: 10.11852/zgetbjzz2025-0775

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Diagnostic value of peripheral blood biomarkers in neurodevelopmental disorders

ZHAO Tingjiao, WEI Hua

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Abstract

Neurodevelopmental disorders are a group of chronic conditions that severely affect children's health and are associated with a high clinical prevalence. Their etiology and pathogenesis remain incompletely understood, and frequent comorbidities further complicate clinical diagnosis. In China, the current diagnostic system mainly relies on expert clinical judgment and behavioral assessment, which is limited by subjectivity, delayed diagnosis, and resource constraints. These challenges underscore the urgent need for objective biomarkers to support accurate and timely clinical decision-making. Compared with biomarkers obtained through invasive procedures,minimally invasive or nonivasive peripheral biospecimens is relatively safe, economical, and feasible for clinical application. Meanwhile, such as saliva, urine, and feces, have also emerged as major focuses of recent research and attracted increasing attention. This review summarizes recent advances in peripheral biomarkers for pediatric neurodevelopmental disorders and discusses their potential value in early diagnosis and clinical application.

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neurodevelopmental disorders / biomarkers / diagnostic value

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ZHAO Tingjiao, WEI Hua. Diagnostic value of peripheral blood biomarkers in neurodevelopmental disorders[J]. Chinese Journal of Child Health Care. 2026, 34(5): 561-565 https://doi.org/10.11852/zgetbjzz2025-0775

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