Meta-analysis of the association between vitamin A levels and tic disorders in children

SONG Siyu; GUO Shuai; XU Xiaolei

doi:10.11852/zgetbjzz2025-0378

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Chinese Journal of Child Health Care ›› 2026, Vol. 34 ›› Issue (5) : 555-560. DOI: 10.11852/zgetbjzz2025-0378

Meta Analysis

Meta-analysis of the association between vitamin A levels and tic disorders in children

SONG Siyu, GUO Shuai,XU Xiaolei

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Abstract

Objective To systematically evaluate the association between vitamin A (VitA) levels and tic disorders (TD) in children, in order to provide new ideas for the prevention of TD. Methods CNKI, VIP, Wanfang, PubMed, Cochrane Library, and Web of Science were searched from inception to January 12, 2025. Two researchers independently screened the literature, extracted data, and assessed study quality. Meta-analysis was performed using RevMan 5.3. Results A total of 7 case-control studies involving 1 401 participants were included, including 901 children in the TD group and 500 in the control group. The pooled results showed that serum VitA levels in children with TD were significantly lower than those in healthy controls (MD=-0.05, 95%CI: -0.08 to -0.02, P=0.002). Subgroup analysis showed no significant difference in serum VitA levels between the Tourette syndrome (TS) group and the chronic motor or vocal tic disorder (CTD) group (MD=0.03, 95%CI:-0.00 to 0.07, P=0.080). Serum VitA levels in the provisional tic disorder (PTD) group tended to be higher than those in the TS group, with borderline significant difference (MD=0.05, 95%CI:-0.00 to 0.09, P=0.050). Serum VitA levels in PTD group were higher than those in CTD group(MD=0.01,95%CI:0.00 to 0.03,P=0.020). In 3 studies, VitA levels in children with mild TD were higher than those in children with moderate-to-severe TD (MD=0.08, 95%CI: 0.05 to 0.11, P<0.001). Conclusions Serum VitA levels are lower in children with TD than in healthy children, and lower VitA levels may be associated with the presence and severity of TD. However, given the limited number of included studies and the substantial heterogeneity, further high-quality studies are needed to confirm these findings.

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tic disorders / vitamin A / Meta-analysis / children

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SONG Siyu, GUO Shuai,XU Xiaolei. Meta-analysis of the association between vitamin A levels and tic disorders in children[J]. Chinese Journal of Child Health Care. 2026, 34(5): 555-560 https://doi.org/10.11852/zgetbjzz2025-0378

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