Research progress of pediatric obesity from the perspective of cellular biomechanics

PENG Zhou; WANG Xiaoyu; GUO Xirong

doi:10.11852/zgetbjzz2025-0303

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (10) : 1086-1090. DOI: 10.11852/zgetbjzz2025-0303

Pediatric Metabolic Diseases Column

Research progress of pediatric obesity from the perspective of cellular biomechanics

PENG Zhou^1,2, WANG Xiaoyu³, GUO Xirong^1,2

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Abstract

In recent years, cellular biomechanics has gained increasing attention in the field of obesity prevention and management.Childhood obesity serves as a critical early intervention window for preventing adult metabolic diseases, and cellular biomechanics may offer novel strategies for addressing this issue.Traditionally, research has focused on macro-level exercise mechanics, but recent studies have delved deeper into cellular and molecular mechanisms.To explore advances in childhood obesity research from a cellular biomechanics perspective, a systematic search was conducted in PubMed, Web of Science, and CNKI databases using keywords such as cellular biomechanics and childhood obesity, covering publications from 2011 to 2025, with over 90% of the included literature from the past five years.This review introduces key biomechanical elements, summarizes findings related to dietary and exercise interventions as well as genetic factors, and discusses future directions for childhood obesity research from a cellular biomechanics standpoint.By exploring these insights, this article aims to inspire new research approaches and serve as a valuable resource for understanding pediatric obesity from a cellular biomechanic perspective.

Key words

cell biomechanics / pediatric obesity / extracellular matrix / mechanical signal transduction / prevention and treatment of obesity

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PENG Zhou, WANG Xiaoyu, GUO Xirong. Research progress of pediatric obesity from the perspective of cellular biomechanics[J]. Chinese Journal of Child Health Care. 2025, 33(10): 1086-1090 https://doi.org/10.11852/zgetbjzz2025-0303

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