Progress on organoid models in the mechanism of the gut-liver- adipose axis in childhood obesity

WANG Tengfei; WANG Zerui; WANG Xingyun

doi:10.11852/zgetbjzz2025-0301

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (10) : 1074-1078. DOI: 10.11852/zgetbjzz2025-0301

Pediatric Metabolic Diseases Column

Progress on organoid models in the mechanism of the gut-liver- adipose axis in childhood obesity

WANG Tengfei¹, WANG Zerui², WANG Xingyun¹

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Abstract

The prevention and treatment of childhood obesity and related metabolic disorders face significant challenges due to mechanistic complexity and marked individual heterogeneity.Current research is hindered by the lack of in vitro models capable of precisely simulating pediatric metabolic characteristics and multi-organ interactions.With breakthroughs in organoid technology, its advantages in 3D structural reconstruction, genetic editing, and cross-organ co-culture have established highly biomimetic model systems for in vitro research.This review focuses on the research demands of childhood obesity, systematically summarizing the construction strategies and application advances of intestinal organoids, hepatic organoid, and adipose organoid.It further addresses critical bottlenecks, including insufficient model standardization, limitations in metabolic microenvironment simulation, and challenges in cross-scale data integration, aiming to provide novel multi-dimensional research strategies and translational pathways for elucidating mechanisms and enabling precision interventions in obesity-related metabolic diseases.

Key words

organoids / obesity / children / inter-organ communication

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WANG Tengfei, WANG Zerui, WANG Xingyun. Progress on organoid models in the mechanism of the gut-liver- adipose axis in childhood obesity[J]. Chinese Journal of Child Health Care. 2025, 33(10): 1074-1078 https://doi.org/10.11852/zgetbjzz2025-0301

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