Cross-species transmission in obesity

WANG Rui; GUO Xirong

doi:10.11852/zgetbjzz2025-0300

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (10) : 1091-1094. DOI: 10.11852/zgetbjzz2025-0300

Pediatric Metabolic Diseases Column

Cross-species transmission in obesity

WANG Rui, GUO Xirong

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Abstract

Childhood obesity has constituted one of the global public health challenges of the 21st century.Changes in dietary structure not only contribute to excessive energy intake, but also regulate human metabolism through cross-species transmission of signal molecules, which plays an important role in the occurrence of childhood obesity.Humans and other species, such as microorganisms and plants, have frequently engaged in cross-species transmission of signal molecules during co-evolution.In addition to horizontal gene transfer, microRNAs, isoenzymes, and metabolites could be transferred across species through the medium of gut microbiota and extracellular vesicles to achieve cross-species regulation of human metabolism.In this study, the recent progress of cross-species transmission and the latest findings of cross-species transmission in obesity are systematically elaborated, in order to provide scientific basis and practical guidance for exploring mechanism of childhood obesity occurrence and formulating prevention and treatment strategies.

Key words

childhood obesity / gut microbiota / cross-species transmission / extracellular vesicles

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WANG Rui, GUO Xirong. Cross-species transmission in obesity[J]. Chinese Journal of Child Health Care. 2025, 33(10): 1091-1094 https://doi.org/10.11852/zgetbjzz2025-0300

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