Super enhancers in obesity-related metabolic diseases

WANG Tongshuai; GUO Xirong

doi:10.11852/zgetbjzz2025-0299

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (10) : 1079-1081. DOI: 10.11852/zgetbjzz2025-0299

Pediatric Metabolic Diseases Column

Super enhancers in obesity-related metabolic diseases

WANG Tongshuai, GUO Xirong

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Abstract

Super-enhancers (SEs) are specialized DNA elements that significantly enhance transcriptional efficiency, driving the expression of genes essential for cellular function.Each cell contains hundreds of SEs, which regulate key gene networks.Dysregulation of SEs has been implicated in the aberrant activation of pathogenic genes in diseases such as Alzheimer's, diabetes, inflammation, and cancer.Despite their significance, the role of SEs in metabolism-related diseases remains underexplored.Metabolic disorders often serve as foundational factors in the development of other chronic conditions.Understanding the involvement of SEs in the initiation and progression of metabolic diseases could provide critical insights and inform the development of effective prevention strategies.This review explores the emerging role of SEs in metabolic disorders and their potential as targets for therapeutic intervention.

Key words

super-enhancers / obesity / transcription / regulatory elements / metabolism

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WANG Tongshuai, GUO Xirong. Super enhancers in obesity-related metabolic diseases[J]. Chinese Journal of Child Health Care. 2025, 33(10): 1079-1081 https://doi.org/10.11852/zgetbjzz2025-0299

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