Mechanisms of Bardet-Biedl syndrome protein complex in childhood obesity and associated metabolic diseases

ZHAN Shumin; FU Junfen

doi:10.11852/zgetbjzz2025-0283

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (10) : 1066-1069. DOI: 10.11852/zgetbjzz2025-0283

Pediatric Metabolic Diseases Column

Mechanisms of Bardet-Biedl syndrome protein complex in childhood obesity and associated metabolic diseases

ZHAN Shumin, FU Junfen

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Abstract

Bardet-Biedl syndrome protein complex (BBSome) is a complex composed of eight proteins associated with Bardet-Biedl syndrome (BBS) that plays a crucial role in ciliary function.It has emerged as an important regulator of energy balance and is closely linked to metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease.Research indicates that BBSome is involved in central energy metabolism, fatty acid metabolism, glucose homeostasis, and the transport of leptin receptors.While most studies have focused on adult models, the symptoms of BBS can be severe in childhood as well.Future research should enhance the understanding of metabolic diseases in early life to elucidate the complex role of BBSome in metabolic regulation.

Key words

Bardet-Biedl syndrome protein complex / Bardet-Biedl syndrome / cilia / childhood obesity / metabolic diseases

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ZHAN Shumin, FU Junfen. Mechanisms of Bardet-Biedl syndrome protein complex in childhood obesity and associated metabolic diseases[J]. Chinese Journal of Child Health Care. 2025, 33(10): 1066-1069 https://doi.org/10.11852/zgetbjzz2025-0283

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