Bone age status of 6 231 children and adolescents in Changchun area

SUN Jiaxiang,SHI Zhong,CAO Lianfu,SUN Liping

Chinese Journal of Child Health Care ›› 2026, Vol. 34 ›› Issue (4) : 427-432.

PDF(1471 KB)
PDF(1471 KB)
Chinese Journal of Child Health Care ›› 2026, Vol. 34 ›› Issue (4) : 427-432. DOI: 10.11852/zgetbjzz2024-1495
Health Promotion

Bone age status of 6 231 children and adolescents in Changchun area

  • SUN Jiaxiang1,SHI Zhong2,CAO Lianfu2,SUN Liping2
Author information +
History +

Abstract

Objective To analyze the characteristics of bone age (BA) distribution and its key influencing factors—specifically gender, age, and nutritional status—among children and adolescents in the Changchun region, in order to provide data support for growth assessment and intervention strategies for related disorders. Methods A cross-sectional study was conducted involving children and adolescents aged 2 - 18 years who visited the Department of Child Health Care at the Children′s Medical Center, Affiliated Hospital of Changchun University of Chinese Medicine, between January 2021 and June 2024. Physical examination and BA data were collected. BA was assessed using the China 05 method, and the bone age difference (BAD) was calculated as BA minus chronological age (CA). Multivariate logistic regression analysis was employed to identify influencing factors. Results A total of 6 231 participants were enrolled. The prevalence of significant BA deviation (|BAD|≥1 year), indicating either advanced or delayed development) was 37.63% (2 345/6 231).The overall mean BAD was (0.17±1.12) year. Significant gender differences in skeletal development were observed, with females exhibiting higher BAD values than males (t=8.501, P<0.05). Nutritional status emerged as a core influencing factor; compared to the normal-weight group, the obesity group showed a significantly increased risk of advanced bone age (OR=4.109, P<0.001), with mean BAD values reaching (1.04±1.12)years for males and (1.20±1.01) years for females. Age stratification analysis indicated that after age 7, BA generally exceeded chronological age (P<0.001). Conclusions Skeletal development among children and adolescents in Changchun region is significantly influenced by gender, age, and nutritional status. Generally, skeletal maturation in females precedes that in males. Overweight and obesity are identified as the primary risk factors for advanced bone age, suggesting that weight management should be prioritized as a critical component of pediatric growth and development healthcare.

Key words

growth and development / adolescents / bone age / obesity

Cite this article

Download Citations
SUN Jiaxiang,SHI Zhong,CAO Lianfu,SUN Liping. Bone age status of 6 231 children and adolescents in Changchun area[J]. Chinese Journal of Child Health Care. 2026, 34(4): 427-432 https://doi.org/10.11852/zgetbjzz2024-1495

References

[1] Martin DD,Wit J M, Hochberg Z,et al.The use of bone age in clinical practice-part 1[J].Horm Res Paediatr,2011,76(1):1-9.
[2] Tanner J, Oshman D, Bahhage F,et al. Tanner-Whitehouse bone age reference values for North American children[J].J Pediatr,1997,131(1 Pt 1):34-40.
[3] Alshamrani K,Offiah AC.Applicability of two commonly used bone age assessment methods to twenty-first century UK children[J].Eur Radiol,2020,30(1):504-513.
[4] 张绍岩,刘丽娟,吴真列,等.中国人手腕骨发育标准—中华05I.TW3-C RUS TW3-C腕骨和RUS-CHN方法[J].中国运动医学杂志,2006,25(5):509-516.
Zhang SY, Liu LJ, Wu ZL ,et al The Skeletal Development Standards of Hand and Wrist for Chinese Children-China05I.TW3-C RUS,TW3-C Carpal,and RUS-CHN Methods[J].Chin J Sports Med,2006,25(5):509-516. (in Chinese)
[5] NCD Risk Factor Collaboration (NCD-RisC).Worldwide trends in body-mass index,underweight,overweight,and obesity from 1975 to 2016:A pooled analysis of 2416 population-based measurement studies in 128.9 million children,adolescents,and adults[J].Lancet, 2017,390(10113):2627-2642.
[6] 周琼,郭玉清,张小宁.母亲养育实践与婴幼儿饮食行为对儿童超重肥胖影响的研究[J].现代预防医学,2022,49(12):2184-2188.
Zhou Q, Guo YQ, Zhang XN. Impact of maternal parenting practices and infant eating behaviors on childhood overweight and obesity[J].Modern Preventive Medicine,2022,49(12):2184-2188.(in Chinese)
[7] Liu G, Guo J, Zhang X, et al. Obesity is a risk factor for central precocious puberty:A case-control study[J].BMC Pediatr,2021,21(1):509.
[8] 李辉,季成叶,宗心南,等.中国0-18岁儿童 青少年体块指数的生长曲线[J].中华儿科杂志,2009,47(7):493-498.
Li H, Ji CY , Zong XN, et al. Body mass index growth curves for Chinese children and adolescents aged 0 to 18 years[J]. Chin J Pediatr,2009,47(7):493-498.(in Chinese)
[9] 中华人民共和国国家卫生和计划生育委员会.学龄儿童青少年超重与肥胖筛查WS/T586-2018[S].北京:中国标准出版社,2018.
National Health and Family Planning Commission of the People′s Republic of China. Screening for overweight and obesity among school-age children and adolescents WS/T586-2018[S]. Beijing:China Standard Press, 2018.
[10] 中华人民共和国国家卫生和计划生育委员会.学龄儿童青少年营养不良筛查标准WS/T456-2014[S].北京:中国标准出版社,2014.
National Health and Family Planning Commission of the People′s Republic of China. Screening standard for malnutrition of school-age children and adolescents WS/T456-2014[S]. Beijing:China Standard Press,2014.
[11] 任慕兰,郑意楠.女性性早熟的诊疗策略[J].实用妇产科杂志,2017,33(8):572-575.
[12] Guaraldi F,Beccuti G,Gori D,et al.Management of endocrine disease: Long-term outcomes of the treatment of central precocious puberty[J].Eur J Endocrinol,2016,174(3):79-87.
[13] 中华医学会儿科学分会内分泌遗传代谢学组,中华儿科杂志编辑委员会.中枢性性早熟诊断与治疗专家共识(2022)[J].中华儿科杂志,2023,61(1):16-22.
The Subspecialty Group of Endocrinologic, Hereditary and Metabolic Diseases, the Society of Pediatrics, Chinese Medical Association; the Editorial Board, Chinese Journal of Pediatrics. Expert consensus on the diagnosis and treatment of central precocious puberty (2022)[J].Chin J Pediatr,2023,61(1):16-22.(in Chinese)
[14] Heras V,Castellano JM,Fernandois D,et al. Central ceramide signaling mediates obesity-induced precocious puberty[J].Cell Metabolism,2020,32(6):951-966.
[15] 许晓琴,章建伟,陈瑞敏,等.中国儿童体质指数与性发育水平的关系[J].中华儿科杂志,2022,60(4):311-316.
Xu XQ, Zhang JW, Chen RM, et al. Relationship between body mass index and sexual development in Chinese children[J].Chin J Pediatr,2022,60(4):311-316.(in Chinese)
[16] Zhou B, Qu X, Li M, et al. Correlation of bone age deve-lopment with overweight and obesity in 23 305 children from Beijing[J]. Endocrine,2025,87(1):304-313.
[17] 刘冰雪,龙也,姜新萍.4~16岁儿童体质量指数对骨龄的影响[J].中国临床研究, 2023,36(6):904-907.
Liu BX, Long Y, Jiang XP. Body mass index on bone age in children aged 4-16[J]. Chin J Clin Res,2023,36(6): 904-907.(in Chinese)
[18] 刘军廷,么鸿雁,于石成,等.中国六省学龄儿童体重指数、体脂百分比评价肥胖与心血管代谢危险因素的相关性[J].中国儿童保健杂志,2022,30(5):469-474.
Liu JT, Yao HY, Yu SC, et al. Association of obesity classified by body mass index and fat mass percentage with cardiometabolic risk factors among school-age children in 6 provinces, China[J]. Chin J Child Health Care,2022,30(5):469-474.(in Chinese)
[19] 杨文聪,翟爽.6~8岁骨龄段女童体质量指数测量及体脂率状况评估分析[J].中国儿童保健杂志,2024,32(1):79-83.
Yang WC,Zhai S. Body mass index and body fat rate evaluation of girls aged 6-8 years[J]. Chin J Child Health Care,2024,32(1):79-83.(in Chinese)
[20] 张天成,杜晓娟.21个少数民族18岁青年生长发育与自然环境差异的关系[J].中华预防医学杂志,2009,43(11):1046-1048.
[21] 罗冬梅,闫晓晋,雷园婷,等.中国7~18岁汉族学生生长迟缓的城乡差异及与地区经济发展的关联分析[J]. 中华预防医学杂志,2019,53(10):1038-1042.
Luo DM, Yan XJ, Lei YT, et al. Analysis on the urban-rural disparity of childhood stunting and its association with economic growth among Chinese Han students aged 7-18 years old[J]. Chin J Prev Med,2019,53 (10):1038-1042.(in Chinese)
[22] 黄卫保,林剑军,梁志杰,等.南宁地区儿童青少年骨龄差异分析[J].医学影像学杂志,2024,34(2):104-108.
Huang WB, Lin JJ, Liang ZJ, et al. Anaysis of bone age differences among children and adolescents in Nanning[J]. J Med Imaging,2024,34(2):104-108.(in Chinese)
[23] 杨锐,闵爱萍,文艺,等.四川省乐山地区青少年儿童骨龄调查分析[J].临床放射学杂志,2019,38(6):1102-1106.
Yang R, Min AP, Wen Y, et al. Analysis of bone age of adolescents in Leshan,Sichuan Province[J].Journal of Clinical Radiology,2019,38(6):1102-1106.(in Chinese)
PDF(1471 KB)

Accesses

Citation

Detail

Sections
Recommended

/