Correlation between serum 25-hydroxyvitamin D and intellectual  development in infants of different months

YANG Qian; ZHANG Jingjie; SHI Ying; LIU Yanmin; ZHANG Yonghua

doi:10.11852/zgetbjzz2024-1318

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (8) : 817-822. DOI: 10.11852/zgetbjzz2024-1318

Original Articles

Correlation between serum 25-hydroxyvitamin D and intellectual development in infants of different months

YANG Qian, ZHANG Jingjie, SHI Ying, LIU Yanmin, ZHANG Yonghua

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Abstract

Objective To analyze the association between serum 25-hydroxyvitamin D [25-(OH)D] levels and intellectual development in infants, and to evaluate the potential influence of vitamin D on their intellectual development. Methods A total of 205 infants who underwent physical examination at the Lanzhou Maternal and Child Health Care Hospital from November 2023 to September 2024 were selected as the study subjects.Their general information was retrospectively described, and the 25-(OH)D levels and developmental quotients (DQ) were recorded at 3, 6, and 12 months of age.The Spearman correlation coefficient was used to analyze the correlation between 25-(OH)D levels and DQ.Multiple linear stepwise regression analysis was employed to explore the independent correlation of 25-(OH)D levels with DQ and the interaction with other factors.Restricted cubic spline curve fitting was used to analyze the dose-response relationship between 25-(OH)D levels and DQ. Results The 25-(OH)D levels of the infants at 3, 6, and 12 months of age were (29.35±10.21) ng/mL, (29.97±8.21) ng/mL, and (33.04±6.11) ng/mL, respectively.Their DQ scores were (89.72±7.03), (90.16±6.38), and (91.08±6.47), respectively.The 25-(OH)D levels at different ages showed a significant positive correlation with DQ (r＝0.496、0.474、0.437,P<0.05).Multiple linear stepwise regression analysis further confirmed that serum 25-(OH)D is a positive influencing factor for intellectual development.The restricted cubic spline curve fitting revealed a non-linear relationship between 25-(OH)D levels and DQ (P_{for overall}<0.05, P_non-linear<0.05), suggesting that the impact of vitamin D on intellectual development was more pronounced within a certain range. Conclusions The 25-(OH)D levels and intellectual development levels of infants in Lanzhou at different months of age are favorable, and there is a close relationship between the two.Therefore, changes in serum 25-(OH)D levels should be regularly monitored in clinical practice, which is important for predicting and promoting intellectual development in children.

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serum 25-hydroxyvitamin D / infants / intellectual development / correlation

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YANG Qian, ZHANG Jingjie, SHI Ying, LIU Yanmin, ZHANG Yonghua. Correlation between serum 25-hydroxyvitamin D and intellectual development in infants of different months[J]. Chinese Journal of Child Health Care. 2025, 33(8): 817-822 https://doi.org/10.11852/zgetbjzz2024-1318

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