Assessment oflongitudinal changes in motor function in children with Duchenne muscular dystrophy using motor function measurement and timed function tests

WANG Yating; HUANG Meihuan; CUI Ruiqing; ZHOU Chunming; ZHONG Jiamin; YUN Guojun

doi:10.11852/zgetbjzz2024-1221

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (12) : 1310-1315. DOI: 10.11852/zgetbjzz2024-1221

Assessment oflongitudinal changes in motor function in children with Duchenne muscular dystrophy using motor function measurement and timed function tests

WANG Yating^1,2, HUANG Meihuan¹, CUI Ruiqing^1,2, ZHOU Chunming¹, ZHONG Jiamin¹, YUN Guojun¹

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Objective To investigate longitudinal changes in motor function outcomes in children with Duchenne muscular dystrophy (DMD) under corticosteroid treatment, in order to provide evidence for clinical management. Methods This longitudinal study included 46 male DMD patients (aged 3 - 14 years) treated at Rehabilitation Department of Shenzhen Children′s Hospital from October 2017 to July 2024.Participants were stratified into preschool and school-age groups.Assessments included basic information, Motor Function Measure-32 (MFM-32) and Timed Function Tests (TFTs).TFTs included the 10-meter walk/run test (10MWR), rise from floor (RFF), and four-step climb (4SC).Spearman′s correlation and paired t-tests were used to analyze the relationships between MFM-32 domains and TFTs at baseline and 12-month follow-up. Results MFM-D1 domain scores showed a strong negative correlation with TFTs (r =-0.665 to -0.614, P < 0.01).In the preschool group, statistically significant differences were observed in the MFM-D1 (t=2.782), D3 (t=2.963), total score (t=3.639), 10MWR (t=-2.138) and 4SC (t=-2.381) (all P<0.05).School-age group demonstrated significant changes in MFM-D1 (t=-4.433), total score (t=-3.427), 10MWR (t=3.15) and RFF (t=2.128) (all P<0.05). Conclusions After 12 months,motor function in the preschool children with DMD shows an overall upward trend, while the school-age children with DMD exhibited a decline. MFM-32 and TFTs are sensitive tools for monitoring motor function progression in DMD.Combined implementation is recommended for comprehensive clinical assessment.

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Duchenne muscular dystrophy / motor function measure / children

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WANG Yating, HUANG Meihuan, CUI Ruiqing, ZHOU Chunming, ZHONG Jiamin, YUN Guojun. Assessment oflongitudinal changes in motor function in children with Duchenne muscular dystrophy using motor function measurement and timed function tests[J]. Chinese Journal of Child Health Care. 2025, 33(12): 1310-1315 https://doi.org/10.11852/zgetbjzz2024-1221

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