Cohort study on the impact of maternal perinatal vaginitis and periodontal disease on allergic diseases in infants

YIN Xiaogang; CHEN Maolin; CAO Hui; GAO Guopeng; XIE Liangliang; TAO Fangbiao YAN Shuangqin

doi:10.11852/zgetbjzz2024-1094

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Chinese Journal of Child Health Care ›› 2026, Vol. 34 ›› Issue (1) : 71-75. DOI: 10.11852/zgetbjzz2024-1094

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Cohort study on the impact of maternal perinatal vaginitis and periodontal disease on allergic diseases in infants

YIN Xiaogang¹, CHEN Maolin¹, CAO Hui¹, GAO Guopeng¹, XIE Liangliang¹, TAO Fangbiao² YAN Shuangqin¹

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Abstract

Objective To analyze the association between maternal perinatal vaginitis, periodontal disease, and the occurrence of allergic disease symptoms in infants within the first year of life. Methods A maternal-infant health cohort was established at Ma'anshan Maternal and Child Health Care Hospital from June 2015 to June 2016. General demographic information of parents and infants, as well as data on perinatal vaginitis and periodontal disease, were collected. Binary logistic regression analysis was used to evaluate the impact of perinatal periodontal disease and vaginitis on the occurrence of allergic disease symptoms in infants within the first year of life. Results A total of 1 760 mother-infant pairs were included in this study. The prevalence rates of vaginitis during the three months before pregnancy, first trimester, and second trimester were 8.6%, 2.6%, and 3.2%, respectively. The prevalence rates of periodontal disease during the three months before pregnancy, first trimester, and second trimester were 44.2%, 39.3%, and 46.9%, respectively. The incidence of allergic disease symptoms in infants within the first year of life was 25.6%. After adjusting for confounding factors, vaginitis during the three months before pregnancy (OR= 1.69, 95%CI: 1.18 - 2.43) and periodontal disease during the second trimester (OR= 1.36, 95% CI: 1.09 - 1.70) were identified as risk factors for the occurrence of allergic disease symptoms in infants. Conclusions Maternal prenatal vaginitis and periodontal disease are risk factors for the development of allergic disease symptoms in infants. It is recommended that women of childbearing age receive treatment for periodontal disease and vaginitis before conception.

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perinatal pregnancy / periodontal disease / vaginitis / allergic diseases / cohort study

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YIN Xiaogang, CHEN Maolin, CAO Hui, GAO Guopeng, XIE Liangliang, TAO Fangbiao YAN Shuangqin. Cohort study on the impact of maternal perinatal vaginitis and periodontal disease on allergic diseases in infants[J]. Chinese Journal of Child Health Care. 2026, 34(1): 71-75 https://doi.org/10.11852/zgetbjzz2024-1094

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