Changes and mechanisms of gut microbiota in children with autism spectrum disorder

ZUMURETI·Yimin; RENA·Maimaiti; WANG Minnan

doi:10.11852/zgetbjzz2024-0960

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (6) : 638-642. DOI: 10.11852/zgetbjzz2024-0960

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Changes and mechanisms of gut microbiota in children with autism spectrum disorder

ZUMURETI·Yimin, RENA·Maimaiti, WANG Minnan

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Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication, restrictive and repetitive behaviors, narrow interests.Recent studies have found that the composition and abundance of gut microbiota are changed in children with ASD, which affect the brain functional development of children through the "microbiota-gut-brain axis", resulting in behavioral development disorder.Currently, there are significant differences in the reported changes in gut microbiome diversity, taxonomic level abundance, and mechanisms of action among children with ASD in different research institutes.Therefore, this article reviews the changes and mechanism of the most common gut microbiota in children with ASD, in order to provide a basis for further study.

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autism spectrum disorder / gut microbiota / microbiota-gut-brain axis / children

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ZUMURETI·Yimin, RENA·Maimaiti, WANG Minnan. Changes and mechanisms of gut microbiota in children with autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2025, 33(6): 638-642 https://doi.org/10.11852/zgetbjzz2024-0960

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