Effects and mechanisms of early exposure to bisphenol substances on children's cardiac development

YANG Mei; YANG Fan; YANG Beibei; LU You

doi:10.11852/zgetbjzz2024-0945

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (5) : 533-536. DOI: 10.11852/zgetbjzz2024-0945

Review

Effects and mechanisms of early exposure to bisphenol substances on children's cardiac development

YANG Mei^1,2, YANG Fan¹, YANG Beibei², LU You¹

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Abstract

The early stages of life are a crucial period for individual growth and development, during which exposure to environmental endocrine-disrupting chemicals can have profound impacts on children's health. Bisphenols (BPs), such as bisphenol A (BPA) and bisphenol S (BPS), are a group of chemical compounds widely used in the manufacture of plastics, food packaging, and various consumer products.Due to its potential endocrine-disrupting properties, the impact of exposure to BPs on children's health has received widespread attention in recent years. The heart, as an important organ of the human body, has a complex and delicate development process that is regulated by various internal and external factors. Studies suggest that early-life exposure to BPs in life may affect embryonic and child cardiac development by simulating or interfering with the effects of endogenous hormones. This review aims to elucidate the impact of BPs on developing hearts and their underlying pathophysiological mechanisms, so as to provide a theoretical foundation for the development of effective preventive and interventional strategies.

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bisphenols / cardiac development / endocrine disruptors / mechanism

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YANG Mei, YANG Fan, YANG Beibei, LU You. Effects and mechanisms of early exposure to bisphenol substances on children's cardiac development[J]. Chinese Journal of Child Health Care. 2025, 33(5): 533-536 https://doi.org/10.11852/zgetbjzz2024-0945

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