Advances in mechanisms underlying autism spectrum disorder in offspring induced by maternal immune activation

WANG Jin; SHEN Kexin; CHEN Jie; DING Yuan

doi:10.11852/zgetbjzz2024-0784

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (11) : 1252-1255. DOI: 10.11852/zgetbjzz2024-0784

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Advances in mechanisms underlying autism spectrum disorder in offspring induced by maternal immune activation

WANG Jin, SHEN Kexin, CHEN Jie, DING Yuan

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Abstract

Autism spectrum disorder(ASD) is a neurodevelopmental disorder primarily characterized by social impairments and repetitive, stereotyped behaviors, resulting from the combined effects of genetic and environmental factors. Maternal immune activation (MIA) has been recognized as one of the significant risk factors for the occurrence of ASD in offspring. Recent studies have implicated MIA in metabolic disorder, disrupted gut microbiota, epigenetic alterations, and neuroinflammation associated with ASD. However, the specific underlying mechanisms remain elusive. Therefore, this study aims to provide theoretical support for the etiology research of ASD by comprehensively reviewing the mechanisms pertaining to the elevated risk of ASD associated with MIA.

Key words

autism spectrum disorder / maternal immune activation / metabolism / gut microbiota / epigenetics / neuroinflammation

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WANG Jin, SHEN Kexin, CHEN Jie, DING Yuan. Advances in mechanisms underlying autism spectrum disorder in offspring induced by maternal immune activation[J]. Chinese Journal of Child Health Care. 2025, 33(11): 1252-1255 https://doi.org/10.11852/zgetbjzz2024-0784

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