Effect of serum uric acid levels on metabolic syndrome and its components in children and adolescents

ZHU Bowen; WANG Tongshuai; WANG Xingyun; GUO Xirong

doi:10.11852/zgetbjzz2024-0565

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (5) : 489-496. DOI: 10.11852/zgetbjzz2024-0565

Original Articles

Effect of serum uric acid levels on metabolic syndrome and its components in children and adolescents

ZHU Bowen, WANG Tongshuai, WANG Xingyun, GUO Xirong

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Abstract

Objective To elucidate the impact of serum uric acid (SUA) on metabolic syndrome (MetS) and its components in children and adolescents, in order to provide a basis for the prevention of MetS in this population. Methods Demographic data, anthropometric measurements, and biochemical indicators were obtained from the China Health and Nutrition Survey (CHNS) database. Logistic regression models were used to assess the association between SUA and MetS. Additive and multiplicative models were employed to evaluate the interaction effects of age, sex, and body mass index (BMI) with SUA on MetS. Results A total of 591 children and adolescents aged 10 - 17 years were included, of whom 8.8% had central obesity, 6.9% had elevated fasting blood glucose, 12.4% had elevated blood pressure, 25.0% had hypertriglyceridemia (high TG), and 9.1% had low high-density lipoprotein (HDL). Hyperuricemia (HUA) was identified as a risk factor for MetS based on both Chinese criteria (OR=18.79,95%CI: 3.08 - 114.66) and Cook criteria (OR=7.53, 95%CI: 1.97 - 28.77). HUA was also significantly positively associated with MetS components, including central obesity, high TG, and low HDL. Subgroup analysis revealed that the associations between HUA and MetS, as well as its components (central obesity and hypertriglyceridemia), were more pronounced in males, the 10 - 12 age group, and the normal-weight group. Conclusion HUA is closely associated with the risk of MetS in children and adolescents, particularly in phenotypes characterized by central obesity, hypertriglyceridemia, and low HDL. These findings suggest that regular monitoring of SUA levels in children and adolescents, along with efforts to prevent HUA, is crucial for reducing the incidence and progression of MetS and related cardiovascular diseases.

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metabolic syndrome / hypericemia / China Health and Nutrition Survey / children and adolescents

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ZHU Bowen, WANG Tongshuai, WANG Xingyun, GUO Xirong. Effect of serum uric acid levels on metabolic syndrome and its components in children and adolescents[J]. Chinese Journal of Child Health Care. 2025, 33(5): 489-496 https://doi.org/10.11852/zgetbjzz2024-0565

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