Objective To investigate the association of urinary levels of epinephrine, norepinephrine, γ-aminobutyric acid (GABA), and taurine with cognitive-behavioral impairment in children with obstructive sleep apnea (OSA), in order to provide scientific evidence for predicting cognitive-behavioral impairment in these patients. Methods A total of 74 children diagnosed with OSA by polysomnography (PSG) at the Respiratory Department of Children′s Hospital of Soochow University between February 2023 and February 2024 were selected as study subjects, along with 30 children with primary snoring (PS) as controls.The Pediatric Quality of Life Inventory (PedsQL) scores and urinary levels of epinephrine, norepinephrine, GABA, and taurine were compared between groups. Results Compared to the PS group, children with OSA exhibited significantly lower PedsQL scores in school functioning (t=2.596, P=0.011) and social functioning (Z=2.506, P=0.012).The OSA group with cognitive-behavioral impairment demonstrated higher urinary epinephrine (F=25.725, P<0.001) and lower taurine levels (F=9.515, P<0.001) than both the PS group and OSA group without cognitive-behavioral impairment.Logistic regression analysis identified urinary epinephrine (OR=1.023, 95%CI: 1.001 - 1.046, P=0.041) and taurine (OR=0.985, 95%CI: 0.974 - 0.997, P=0.014) as significant independent predictors of cognitive-behavioral impairment in children with OSA. Conclusion Urinary epinephrine and taurine levels are dysregulated in children with OSA, with taurine demonstrating a potential protective effect against cognitive-behavioral impairment.
Key words
obstructive sleep apnea /
cognitive impairment /
neurotransmitters /
children
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