Genetic advances in the fetal ventriculomegaly

ZHAO Chenyue; ZHANG Lixue; JIANG Jinsong; GUO Min; GAO Jingbo; GUO Rong; CAO Guizhi; XUE Huiqin

doi:10.11852/zgetbjzz2024-0019

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Chinese Journal of Child Health Care ›› 2024, Vol. 32 ›› Issue (12) : 1322-1327. DOI: 10.11852/zgetbjzz2024-0019

Review

Genetic advances in the fetal ventriculomegaly

ZHAO Chenyue¹, ZHANG Lixue¹, JIANG Jinsong¹, GUO Min¹, GAO Jingbo², GUO Rong², CAO Guizhi², XUE Huiqin²

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Abstract

Ventriculomegaly (VM) is a common fetal ultrasound abnormality in prenatal screening,with an incidence of about 1%,and is closely related to the intellectual and psychomotor development of children,which can be evaluated by prenatal ultrasound or MRI that can assess its size and morphology.VM can be caused by central nervous system malformations,chromosomal aberrations,gene mutations,genetic syndromes and potential fetal anomalies,with genetics etiology accounting for a large portion of the cases and has become a concern for many families.This review combs genetic advances in fetal VM,including the genetics etiology and its associated molecular mechanisms,as well as the diagnosis and identification of genetic etiologies.

Key words

fetal lateral ventricular widening / genetic etiology / chromosomal abnormalities / monogenic gene disorder

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ZHAO Chenyue, ZHANG Lixue, JIANG Jinsong, GUO Min, GAO Jingbo, GUO Rong, CAO Guizhi, XUE Huiqin. Genetic advances in the fetal ventriculomegaly[J]. Chinese Journal of Child Health Care. 2024, 32(12): 1322-1327 https://doi.org/10.11852/zgetbjzz2024-0019

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