Association of vitamins and trace elements level with autism spectrum disorder

ZHAO Tingting, SUN Hao, ZHANG Panpan, XIAO Xuwu

Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (1) : 77-82.

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (1) : 77-82. DOI: 10.11852/zgetbjzz2023-1194
Review

Association of vitamins and trace elements level with autism spectrum disorder

  • ZHAO Tingting1,2, SUN Hao1, ZHANG Panpan1, XIAO Xuwu1
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Abstract

Autism spectrum disorders (ASD) is a complex neurodevelopmental disorder, and its etiology remains unclear. Some studies have suggested that children with ASD may have abnormal levels of vitamins and trace elements in their bodies, and supplementing the corresponding vitamins and trace elements can improve the clinical symptoms of ASD children to some extent. However, the specific mechanisms are still unknown. From the metabolic and physiological perspectives of vitamins and trace elements,this review combs relevant researches from domestic and international sources on the correlation between ASD and vitamins and trace elements. It further discusses the potential mechanisms of how these vitamins and trace elements act in ASD, aiming to provide new perspectives and directions for the clinical treatment.

Key words

autism spectrum disorder / vitamins / micronutrient / children

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ZHAO Tingting, SUN Hao, ZHANG Panpan, XIAO Xuwu. Association of vitamins and trace elements level with autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2025, 33(1): 77-82 https://doi.org/10.11852/zgetbjzz2023-1194

References

[1] King DL, Delfabbro PH. The cognitive psychology of Internet gaming disorder[J]. Clin Psychol Rev, 2014, 34(4): 298-308.
[2] Maenner MJ, Warren Z, Williams AR, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years-autism and developmental disabilities Monitoring Network, 11 Sites, United States, 2020[J]. MMWR Surveill Summ,2023,72(2):1-14.
[3] 中华人民共和国卫生部.儿童孤独症诊疗康复指南(卫办医政发〔2010〕123号)[J].中国儿童保健杂志, 2011, 19(3):289-294.
Chinese Ministry of Health.Guidelines for Diagnosis, Treatment, and Rehabilitation of Autism in Children (Health Office Medical and Political Affairs[2010] No. 123)[J].Chin J Child Health Care,2011, 19 (3):289-294. (in Chinese)
[4] 程波利. 维生素 A 对孤独症儿童肠神经系统及胃肠功能的影响及可能机制[D]. 重庆: 重庆医科大学, 2020.
Cheng BL The effects and possible mechanisms of vitamin A on the intestinal nervous system and gastrointestinal function in children with autism[D].Chongqing: Chongqing Medical University, 2020. (in Chinese)
[5] Wołoszynowska-Fraser MU, Kouchmeshky A, McCaffery P. Vitamin A and retinoic acid in cognition and cognitive disease[J]. Annu Rev Nutr, 2020, 40: 247-272.
[6] Lai X, Wu X, Hou N, et al. Vitamin A deficiency induces autistic-like behaviors in rats by regulating the RARβ-CD38-Oxytocin axis in the hypothalamus[J]. Mol Nutr Food Res, 2018, 62(5): 1700754.
[7] Guo M, Zhu J, Yang T, et al. Vitamin A and vitaminD deficiencies exacerbate symptoms in children with autism spectrum disorders[J]. Nutr Neurosci, 2019, 22(9): 637-647.
[8] Cheng B, Zhu J, Yang T, et al. Vitamin A deficiency exacerbates autism-like behaviors and abnormalities of the enteric nervous system in a valproic acid-induced rat model of autism[J]. Neurotoxicology, 2020, 79: 184-190.
[9] 柯海劲, 邓钰红, 吴春艳, 等. 儿童早期维生素 D 水平与神经发育的关系[J]. 中国妇幼保健, 2018, 33(15): 3463P-3465.
Ke HJ, Deng YH, Wu CY, et al. The relationship between early vitamin D levels and neurodevelopment in children[J].Maternal and Child Health Care of China, 2018, 33 (15): 3463-3465. (in Chinese)
[10] Ali A, Vasileva S, Langguth M, et al. Developmental vitamin D deficiency produces behavioral phenotypes of relevance to autism in an animal model[J]. Nutrients, 2019, 11(5): 1187.
[11] Sourander A, Upadhyaya S, Surcel H M, et al. Maternal vitamin D levels during pregnancy and offspring autism spectrum disorder[J]. Biol Psychiatry, 2021, 90(11): 790-797.
[12] Wu DM, Wen X, Han XR, et al. Relationship between neonatal vitamin D at birth and risk of autism spectrum disorders: The NBSIB study[J]. J Bone Miner Res, 2018, 33(3): 458-466.
[13] 董涵宇, 王冰, 李洪华, 等. 孤独症谱系障碍患儿维生素 D 水平与孤独症核心症状相关性研究[J]. 中华儿科杂志, 2017, 55(12): 916-919.
Dong HY, Wang B, Li HH, et al. A study on the correlation between vitamin D levels and core symptoms of autism in children with autism spectrum disorder[J]. Chin J Pediatr, 2017, 55 (12): 916-919. (in Chinese)
[14] Feng J, Shan L, Du L, et al. Clinical improvement following vitamin D3 supplementation in autism spectrum disorder[J]. Nutr Neurosci, 2017, 20(5): 284-290.
[15] Traglia M, Windham G C, Pearl M, et al. Genetic contributions to maternal and neonatal vitamin D levels[J]. Genetics, 2020, 214(4): 1091-1102.
[16] Yu GS, Xu MZ, Chen Y, et al. 25 (OH) Vitamin D and autism spectrum disorder: Genetic overlap and causality[J]. Genes Nutr, 2023, 18(1): 8.
[17] 邹明扬, 武丽杰. 叶酸与儿童孤独症谱系障碍关联的循证医学证据[J]. 中国学校卫生, 2018, 39(3): 473-476.
Zou MY, Wu LJ. Evidence based medicine for the association between folic acid and autism spectrum disorders in children[J]. Chin J Sch Health, 2018, 39 (3): 473-476. (in Chinese)
[18] 王琳琳, 任爱国. 叶酸受体抗体与出生缺陷[J]. 中国生育健康杂志, 2011,22(1):60-61,64.
Wang LL, Ren AG. Folate receptor antibodies and birth defects[J]. Chinese Journal of Reproductive Health, 2011,22(1):60-61,64. (in Chinese)
[19] Zhou J, Liu A, He F, et al. High prevalence of serum folate receptor autoantibodies in children with autism spectrum disorders[J]. Biomarkers, 2018, 23(7): 622-624.
[20] Sequeira JM, Desai A, Berrocal-Zaragoza MI, et al. Exposure to folate receptor alpha antibodies during gestation and weaning leads to severe behavioral deficits in rats: A pilot study[J]. PLoS One, 2016, 11(3): e0152249.
[21] Hoxha B, Hoxha M, Domi E, et al. Folic acid and autism:A systematic review of the current state of knowledge[J]. Cells, 2021, 10(8): 1976.
[22] Liu X, Zou M, Sun C, et al. Prenatal folic acid supplements and offspring's autism spectrum disorder: A meta-analysis and meta-regression[J]. J Autism Child Schizophr, 2022: 1-18.
[23] 蔡小凡, 郭敏, 刘李燕, 等.叶酸和维生素B12与孤独症谱系障碍儿童症状和发育水平相关性研究[J].中国实用儿科杂志,2021,36(7):514-517.
Cai XF, Guo M, Liu LY, et al. A study on the correlation between folic acid and vitamin B12 with symptoms and developmental levels in children with autism spectrum disorders[J]. Chin J Prac Pediatr, 2021,36 (7): 514-517. (in Chinese)
[24] Cruz-Rodríguez J, Díaz-López A, Canals-Sans J, et al. Maternal vitamin B12 Status during pregnancy and early infant neurodevelopment: The ECLIPSES Study[J]. Nutrients, 2023, 15(6): 1529.
[25] Ars CL, Nijs IM, Marroun HE, et al. Prenatal folate, homocysteine and vitamin B12 levels and child brain volumes, cognitive development and psychological functioning:The Generation R Study[J]. Br J Nutr, 2019, 122(Suppl 1): 1-9.
[26] Nesa A, Sultana GS. Study of homocysteine, vitamin B12 and folate in children with autism spectrum disorder[J]. Bangladesh Med Res Counc Bull. 2023:127-132.
[27] 吴梅荣, 熊忠贵, 金正江, 等. 25-羟维生素D维生素B(12)及叶酸对2~6岁孤独症谱系障碍儿童智力及核心症状的影响[J].中国妇幼保健,2021,36(11):2443-2446.
Wu MR, Xiong ZG, Jin ZJ, et al The effects of 25 hydroxyvitamin D, vitamin B (12), and folic acid on intelligence and core symptoms in children with autism spectrum disorder aged 2-6 years old[J]. Maternal and Child Health Care of China, 2021,36 (11): 2443-2446. (in Chinese)
[28] Wang T, Zhang T, Sun L, et al. Gestational B-vitamin supplementation alleviates PM2. 5-induced autism-like behavior and hippocampal neurodevelopmental impairment in mice offspring[J]. Ecotoxicol Environ Saf, 2019, 185: 109686.
[29] Rossignol DA, Frye RE. The effectiveness of cobalamin (B12) treatment for autism spectrum disorder: a systematic review and meta-analysis[J]. J Pers Med, 2021, 11(8): 784.
[30] Ueland P M, McCann A, Midttun Ø, et al. Inflammation, vitamin B6 and related pathways[J]. Mol Aspects Med, 2017, 53: 10-27.
[31] Belardo A, Gevi F, Zolla L. The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children[J]. J Nutr Biochem, 2019, 70: 38-46.
[32] Barnhill K, Gutierrez A, Ghossainy M, et al. Dietary status and nutrient intake of children with autism spectrum disorder: A case-control study[J]. Res Autism Spectr Disord, 2018, 50: 51-59.
[33] Hossain KS, Amarasena S, Mayengbam S. B vitamins and their roles in gut health[J]. Microorganisms, 2022, 10(6): 1168.
[34] Mayengbam S, Chleilat F, Reimer RA. Dietary vitamin B6 deficiency impairs gut microbiota and host and microbial metabolites in rats[J]. Biomedicines, 2020, 8(11): 469.
[35] Fattorusso A, Di Genova L, Dell'Isola GB, et al. Autism spectrum disorders and the gut microbiota[J]. Nutrients, 2019, 11(3): 521.
[36] Li Y, Luo ZY, Hu YY, et al. The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice[J]. Microbiome, 2020, 8: 1-23.
[37] Janssen JJE, Grefte S, Keijer J, et al. Mito-nuclear communication by mitochondrial metabolites and its regulation by B-vitamins[J]. Front Physiol, 2019, 10: 78.
[38] Rangaraju V, Lewis TL, Hirabayashi Y, et al. Pleiotropic mitochondria: the influence of mitochondria on neuronal development and disease[J]. J Neurosci, 2019, 39(42): 8200-8208.
[39] Dhir S, Tarasenko M, Napoli E, et al. Neurological, psychiatric, and biochemical aspects of thiamine deficiency in children and adults[J]. Front Psychiatry, 2019, 10: 207.
[40] Scassellati C, Bonvicini C, Benussi L, et al. Neurodevelopmental disorders: Metallomics studies for the identification of potential biomarkers associated to diagnosis and treatment[J]. J Trace Elem Med Biol, 2020, 60: 126499.
[41] Russo AJ, Devito R. Analysis of copper and zinc plasma concentration and the efficacy of zinc therapy in individuals with Asperger's syndrome, pervasive developmental disorder not otherwise specified (PDD-NOS) and autism[J]. Biomarker insights, 2011, 6:S7286.
[42] Abd Wahil MS, Ja'afar MH, Md Isa Z. Assessment of urinary Lead (Pb) and essential trace elements in autism spectrum disorder: A case-control study among preschool children in Malaysia[J]. Biol Trace Elem Res, 2022, 200(1): 97-121.
[43] Lakshmi Priya MD, Geetha A. Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism[J]. Biol Trace Elem Res, 2011, 142: 148-158.
[44] Baj J, Flieger W, Flieger M, et al. Autism spectrum disorder:Trace elements imbalances and the pathogenesis and severity of autistic symptoms[J]. Neurosci Biobehav Rev, 2021, 129: 117-132.
[45] 张羽珊,于梦雪,阿斯木古丽·克力木.孤独症谱系障碍儿童全血多种元素水平分析与诺模图的构建[J].教育生物学杂志,2021,9(2):109-113,134.
Zhang YS, Yu MX, Asmuguli KLM. Analysis of multiple element levels in whole blood of children with autism spectrum disorder and construction of a nomogram[J]. J Educational Biology, 2021, 9(2): 109-113,134. (in Chinese)
[46] Botturi A, Ciappolino V, Delvecchio G, et al. The role and the effect of magnesium in mental disorders:A systematic review[J]. Nutrients, 2020, 12(6): 1661.
[47] 张鑫慧,杨亭,陈洁,等.孤独症谱系障碍儿童血清微量元素水平与核心症状间关系的全国多中心调查[J].中国当代儿科杂志,2021,23(5):445-450.
Zhang XH, Yang T, Chen J, et al. A national multicenter survey on the relationship between serum trace element levels and core symptoms in children with autism spectrum disorder[J]. Chin J Contemp Pediatr, 2021,23(5): 445-450.(in Chinese)
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