Advances in the treatment of autism spectrum disorder by fecal microbiota transplantation

WANG Lihong; YU Lianhu; CAO Aihua

doi:10.11852/zgetbjzz2023-1151

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Chinese Journal of Child Health Care ›› 2025, Vol. 33 ›› Issue (1) : 83-87. DOI: 10.11852/zgetbjzz2023-1151

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Advances in the treatment of autism spectrum disorder by fecal microbiota transplantation

WANG Lihong, YU Lianhu, CAO Aihua

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Abstract

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired social interactions and communications together with repetitive and restrictive behaviors.The pathogenesis of ASD is complex and heterogeneous.Genetic and environmental factors are associated with the development of ASD.Current researches proposed gut microbiota dysbiosis may be an important trigger in the development of ASD,so the exploration of significant differences in the gut microbiota and metabolomics between individuals with ASD and typically developed individuals may have great significance for understanding the pathogenesis of ASD and clinical diagnosis and treatment.Behavioral interventions are the mainstay of ASD treatment,but their efficacy is limited.Recently,treatments based on the theory of correcting gut microbiota disturbance and restoring intestinal homeostasis have emerged,among which fecal bacteria transplantation is the most representative.In this review,the progress of gut microbiota dysbiosis and metabolomic changes in the occurrence and development of ASD is summarized,and the current research status of fecal microbiota transplantation intervention in ASD population is elucidated,so as to provide new insights for future fecal microbiota transplantation research.

Key words

autism spectrum disorder / fecal microbiota transplantation / brain-gut-axis / metabolic disturbance

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WANG Lihong, YU Lianhu, CAO Aihua. Advances in the treatment of autism spectrum disorder by fecal microbiota transplantation[J]. Chinese Journal of Child Health Care. 2025, 33(1): 83-87 https://doi.org/10.11852/zgetbjzz2023-1151

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