Characteristics of resting-state functional magnetic resonance imaging in adolescents with major depressive disorder comorbid anxious distress

LI Gaizhi; QIAO Dan; NIU Ying; WEN Yujiao; LIU Zhifen; ZHANG Kerang

doi:10.11852/zgetbjzz2023-0745

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (12) : 1286-1291. DOI: 10.11852/zgetbjzz2023-0745

Characteristics of resting-state functional magnetic resonance imaging in adolescents with major depressive disorder comorbid anxious distress

LI Gaizhi^1,2, QIAO Dan¹, NIU Ying³, WEN Yujiao², LIU Zhifen², ZHANG Kerang^1,2

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Abstract

Objective To assess the neuroimaging characteristics of adolescents with major depressive disorder (MDD) comorbid anxious distress, in order to understand the underlying neuro-mechanism. Methods A convenient sample of 27 adolescents with MDD with anxious distress who visited the outpatient clinic of the Department of Psychiatry of the First Hospital of Shanxi Medical University from January to December 2022, and 36 healthy controls were included in this study. All participants completed a case report form and underwent fMRI data collection.Difference in general demographic data and fMRI data between the two groups were compared,and the correlation between the differentiated brain areas and clinial symptoms was analyzed. Results No significant difference was observed in age and gender between the two groups(P>0.05). However, after adjusting for age, gender and educational level, the Bc value in the left middle occipital gyri (MOG) was significantly higher in MDD with anxious distress group (P<0.05, FDR correction). Additionally, the NCp/NLe value of the bilateral inferior occipital gyri (IOG) and NLe of the left cuneus were significantly lower compared to the healthy control group (P<0.05, FDR correction).However, the Bc/NCp/NLe value of the differentiated brain areas did not show any correlation with the scores on the Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) (P＞0.05, FDR correction). Conclusions The topology properties of adolescents with MDD and anxious distress differ from those of healthy controls, particularly in the bilateral IOG, left cuneus, and MOG. These findings further the understanding of MDD with anxious distress.

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major depressive disorder / anxious distress / adolescent

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LI Gaizhi, QIAO Dan, NIU Ying, WEN Yujiao, LIU Zhifen, ZHANG Kerang. Characteristics of resting-state functional magnetic resonance imaging in adolescents with major depressive disorder comorbid anxious distress[J]. Chinese Journal of Child Health Care. 2023, 31(12): 1286-1291 https://doi.org/10.11852/zgetbjzz2023-0745

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