Effects of maternal anesthesia exposure during pregnancy on pregnancy outcome and neurodevelopment of offspring

PENG Rui; YUAN Hongmei

doi:10.11852/zgetbjzz2023-0109

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (11) : 1225-1229. DOI: 10.11852/zgetbjzz2023-0109

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Effects of maternal anesthesia exposure during pregnancy on pregnancy outcome and neurodevelopment of offspring

PENG Rui, YUAN Hongmei

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Abstract

With the improvement of medical technology, an increasing number of women need to receive anesthesia during pregnancy because of surgery, and medical workers gradually pay attention to the impact of anesthesia exposure during pregnancy on the neurodevelopment of offspring. Much of exploration of the neurotoxicity of anesthetics comes from preclinical studies in rodents and nonhuman primates, which are different from the data of these animal studies and previous retrospective cohort studies in humans. Human studies in this field are limited and currently inconclusive. In 2016, the United States Food and Drug Administration issued a warning regarding impaired brain development after exposure to certain anesthetic agents used for general anesthesia in the third trimester of pregnancy. Furthermore, it is also recommended that healthcare professionals balance the benefits and potential risks of anesthesia in infants and pregnant women. However, women may be exposed to narcotic drugs at any stage of pregnancy. Therefore, this paper summarizes the effects of maternal exposure to general anesthesia during early (<14 weeks), mid(14 - 27 weeks), and late pregnancy(≥28 weeks) on the neurodevelopment and cognitive function of their offspring.

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pregnancy / anesthesia exposure / offspring / neurodevelopment

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PENG Rui, YUAN Hongmei. Effects of maternal anesthesia exposure during pregnancy on pregnancy outcome and neurodevelopment of offspring[J]. Chinese Journal of Child Health Care. 2023, 31(11): 1225-1229 https://doi.org/10.11852/zgetbjzz2023-0109

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