Circadian clock and attention deficit hyperactivity disorder

HUANG Huifang, CHEN Yanhui, HUANG Yuxian

Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (11) : 1230-1234.

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (11) : 1230-1234. DOI: 10.11852/zgetbjzz2022-1546
Review

Circadian clock and attention deficit hyperactivity disorder

  • HUANG Huifang, CHEN Yanhui, HUANG Yuxian
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Abstract

The circadian clock produces a stable 24-hour circadian rhythm, which plays a crucial role in sleep, attention, learning, memory and cognition. Attention deficit hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders in children. Circadian rhythm system dysfunction and sleep problems are found to be more common in ADHD compared to healthy children these years, which can worsen the symptoms of ADHD in turn. The circadian clock can regulate various physiological and biochemical processes related to ADHD, including hypothalamus-pituitary-adrenal axis, monoaminergic neurotransmitter system. This review will address the interaction between circadian system and processes above as well as their potential role in the development of ADHD.

Key words

circadian clock / circadian rhythms / attention deficit hyperactivity disorder / hypothalamus-pituitary-adrenal axis / monoaminergic neurotransmitter system

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HUANG Huifang, CHEN Yanhui, HUANG Yuxian. Circadian clock and attention deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2023, 31(11): 1230-1234 https://doi.org/10.11852/zgetbjzz2022-1546

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