Association between genetic variation of ionized glutamate receptors and attention deficit hyperactivity disorder

XIONG Ping; ZHU Hongmin; HUANG Xin; WU Jing; LIN Jing; ZHONG Yanyan

doi:10.11852/zgetbjzz2022-1372

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (9) : 945-950. DOI: 10.11852/zgetbjzz2022-1372

Original Articles

Association between genetic variation of ionized glutamate receptors and attention deficit hyperactivity disorder

XIONG Ping¹, ZHU Hongmin¹, HUANG Xin², WU Jing², LIN Jing³, ZHONG Yanyan³

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Abstract

Objective To analyze the association between genetic variation of ionized glutamate receptors (iGluRs) and attention deficit hyperactivity disorder (ADHD), so as to provide a theoretical basis for elucidating the pathogenesis of ADHD. Methods A case-control study was conducted for the potential candidate genes of ADHD, including GRIN2A, GRIN2B, GRIK1, GRIK4 and GRID2. A total of 320 ADHD children were recruited as the ADHD group in Wuhan Children's Hospital from August 2018 to December 2019, meanwhile 355 typically developed children were enrolled in the control group. All children were evaluated by Conners Parental Syndrome Questionnaire (PSQ). The associations of a single site with the risk of ADHDand ADHD symptoms were examined. Results There were no significant differences in age, sex ratio and intelligence quotient between the ADHD and control groups (P>0.05). The TT genotype frequency of rs1385405 locus on GRID2 gene showed a significant difference between the two groups (P=0.001). Individuals carrying the TT genotype at this locus were 2.725 times more likely to develop ADHD than those carrying the GG genotype (OR=2.725). In the ADHD-C subtype, there was a significant difference between the genotype frequency of this polymorphic locus (P=0.004). The risk of ADHD-C in individuals carrying TT genotype was 2.343 times as high as that in individuals carrying GG genotype (OR=2.343). In addition, there was an association between this locus and ADHD symptoms, with a significant difference in total PSQ scores among individuals carrying different genotypes (F=6.711, P=0.001). Conclusion GRID2-rs1385405 is associated with the susceptibility of ADHD in Chinese Han children, and TT genotype is a risk factor.

Key words

ionic glutamate receptor / attention deficit hyperactivity disorder / heredity / gene

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XIONG Ping, ZHU Hongmin, HUANG Xin, WU Jing, LIN Jing, ZHONG Yanyan. Association between genetic variation of ionized glutamate receptors and attention deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2023, 31(9): 945-950 https://doi.org/10.11852/zgetbjzz2022-1372

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