Association between bone development and vitamin K in children aged 0 to 14 years

YANG Yuru; WANG Hong; XU Shuhong; CAO Yanmei; MENG Xian; GE Dongmei

doi:10.11852/zgetbjzz2022-1274

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (7) : 746-750. DOI: 10.11852/zgetbjzz2022-1274

Basic Experimental Articles

Association between bone development and vitamin K in children aged 0 to 14 years

YANG Yuru¹, WANG Hong¹, XU Shuhong², CAO Yanmei³, MENG Xian¹, GE Dongmei¹

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Abstract

Objective To explore the association between bone development and vitamin K in 6 335 children aged 0 to 14 years, in order to provide a theoretical basis for future clinical intervention of abnormal bone development in children. Methods From January 2020 to April 2022, 6 335 children aged 0 to 14 years who took physical examination in the child health department of several maternal and child health hospitals in Sichuan Province were selected in this study. Serum levels of vitaminK₁ and K₂ were tested by liquid tandem mass spectrometry, meanwhile, the conditions of bone development was recorded. The children were divided into normal group (n=5 040) and abnormal group (n=1 295) according to the bone development result. Then the differences between the two groups were analyzed, andthe influencing factors of bone development in children,especillythe relationship between abnormal bone development and vitamin K was analyzed by Logistic regression. Results There were significant differences in gender(χ²=6.03), age(Z=14.32), height(Z=16.35), weight(Z=16.70), serum vitamin D(Z=8.26),K₁(Z=5.70) and K₂(χ²=13.88) between normal bone development group and abnormal bone development (P＜0.05). The detection rate of skeletal dysplasia in children at different age groups was statistically significant (χ²=158.66, P<0.05). There was no significant difference in the proportion of vitamin K₂<0.10ng/mL among different age groups (P>0.05), but the level of vitamin K1 among different age groups was statistically significant (Z=36.5, P<0.05). The levels of vitamin K₂ and K₁ in children among different ages in the normal group were compared, and the difference was statistically significant (χ²=47.58, Z=582.65, P<0.05).Logistic regression analysis showed that female(OR=0.857,95%CI:0.755-0.973) and weight (OR=0.949,95%CI:0.931-0.968) were protective factors of bone development in children (P<0.05) , height (OR=1.044,95%CI:1.034-1.054) , and vitamin K₂<0.1ng/mL(OR=1.153,95%CI:1.006-1.320) were risk factors for bone development in children(P<0.05). Conclusions The development of children's bones is influenced by various factors.Among vitamin K, it is mainly vitamin K₂ that affects children′s bone development, and children with vitamin K₂< 0.1ng/mL are more likely to have abnormal bone development than children with vitamin K₂≥0.1ng/mL. Monitoring and intervening vitamin K₂ level in children is of certain clinical significance for the early prevention of abnormal bone development diseases.

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bone development / vitamin K / children

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YANG Yuru, WANG Hong, XU Shuhong, CAO Yanmei, MENG Xian, GE Dongmei. Association between bone development and vitamin K in children aged 0 to 14 years[J]. Chinese Journal of Child Health Care. 2023, 31(7): 746-750 https://doi.org/10.11852/zgetbjzz2022-1274

References

[1] 何易祥,赵宇昊,高昭,等. B淋巴细胞及相关细胞因子在骨免疫系统中对破骨细胞分化的作用[J]. 中国组织工程研究,2021,25(29):4709-4714.
He YX,Zhao YH,Gao Z,et al.Effect of B lymphocytes and related cytokines on osteoclast differentiation in the osteoimmunology system[J].Chinese J Tissue Eng Res, 2010,25(29):4709-4714.(in Chinese)
[2] 邹学辉,唐艺玮,马苏娟,等. 成都市儿童及青少年骨骼发育特点及与维生素A、D的关系[J]. 河北医药,2020,42(23):3651-3653.
Zou XH,Tang YW,Ma SJ,et al.The skeleton development characteristics of children and adolescents in Chengdu city and its correlation with vitamin A and vitamin D[J].Hebei Medical Journal,2020,42(23):3651-3653.(in Chinese)
[3] Kanta P, Gopinathan NR. Idiopathic growing pains in pediatric patients:Review of literature[J]. Clin Pediatr (Phila), 2019,58(1):5-9.
[4] Lu L, Chen X, Liu Y, et al. Gut microbiota and bone metabolism[J]. FASEB J,2021,35(7):e21740.
[5] Benhissen Z, Benaim C. Douleurs de la jambe:Diagnostic différentiel et traitement[Leg pain:Differential diagnosis and treatment][J]. Rev Med Suisse,2019,15(635):216-220.
[6] Wang QY, Fu SJ, Ding N, et al. Clinical features, diagnosis and treatment of Paget′s disease of bone in mainland China:A systematic review[J]. Rev Endocr Metab Disord,2020,21(4):645-655.
[7] 杜长秀,李娜.1732例儿童血清维生素K₂临床分析及其与骨代谢标志物关系的研究[J]. 中国当代儿科杂志,2022,24(10):1130-1135.
Du CX,Li N.Serum vitamin K₂ level and its association with bone metabolism markers in 1732 children[J].Chin J Contemp Pediatr,2022,24(10):1130-1135.(in Chinese)
[8] 胡雪松,覃佳强,郭彬,等. 维生素K治疗儿童废用性骨质疏松的疗效观察[J]. 西部医学,2018,30(5):704-706.
Hu XS,Qin JQ,Guo B,et al.Efficacy of vitamin K for the treatment of disuse osteoporosis in children[J].Med J West China,2018,30(5):704-706.(in Chinese)
[9] Sato T,Inaba N, Yamashita T. MK-7 and its effects on bone quality and strength[J]. Nutrients,2020,12(4):965.
[10] Kojima A,Ikehara S, Kamiya K, et al. Natto intake is inversely associated with osteoporotic fracture risk in postmenopausal Japanese women[J]. J Nutr,2020,150(3):599-605.
[11] 黎海芪,毛萌,李辉,等.实用儿童保健学[M].北京:人民卫生出版社,2016.
Li HQ,Mao M,Li H,et al.The principle and practice of pediatric primary xare[M].Beijing:People′s Medical Publishing House,2016.(in Chinese)
[12] 完颜泽伟. 维生素K缺乏与儿童骨代谢异常相关性研究[D].合肥:安徽医科大学,2021.
Wanyan ZW.Study on the correlation between vitamin K deficiency and abnormal bone metabolism in children[D].Hefei:Anhui Medical University,2021.(in Chinese)
[13] 赵笛辰,李梅. 儿童及青少年骨骼发育特点及其影响因素[J]. 中华骨质疏松和骨矿盐疾病杂志,2018,11(6):608-612.
Zhao DC,Li M.Characters of bone development in children and adolescents and its influencing factors[J].Chinese Journal of Osteoporosis and Bone Mineral Research,2018,11(6):608-612.(in Chinese)
[14] 陈淑玲,赵瑾珠,郝燕. 维生素K与儿童骨健康的研究进展[J]. 中国儿童保健杂志,2021,29(7):742-745.
Chen SL,Zhao JZ,Hao Y.Research advangces on vitamin K and bone health in children[J].Chin J Child Health Care,2021,29(7):742-745.(in Chinese)
[15] 彭艳.矮小症儿童骨密度与血清维生素A、D、K水平的关系[J].中国当代医药,2020,27(7):131-134.
Peng Y.Relationship between bone mineral density and serum vitamin A, D and K levels in children with dwarfism[J].Mod Med Asia,2020,27(7):131-134.(in Chinese)
[16] Capozzi A, Scambia G, Lello S. Calcium, vitamin D, vitamin K₂, and magnesium supplementation and skeletal health[J]. Maturitas,2020,140:55-63.
[17] 康丽娟,李宝强,徐传伟. 维生素K对营养性维生素D缺乏性佝偻病患儿骨钙素羧化率的影响[J].儿科药学杂志,2018,24(10):19-21.
Kang LJ,Li BQ,Xu CW.Effect of vitamin K on osteocalcin carboxylation rate in children with nutritional vitamin D deficiency rickets[J].Journal of Pediatric Pharmacy,2018,24(10):19-21.(in Chinese)
[18] 刘黎明,帖利军,史晓薇,等.维生素K与儿童健康关系的研究[J].中国妇幼健康研究,2019,30(9):1039-1047.
Liu LM,Li LJ,Shi XW,et al.Research progress on the relationgship between vitamin K and children′s health[J].Chinese Journal of Woman and Child Health Research,2019,30(9):1039-1047.(in Chinese)
[19] Rodríguez-Olleros Rodríguez C, Díaz Curiel M. Vitamin K and bone health:A review on the effects of vitamin K deficiency and supplementation and the effect of non-vitamin K antagonist oral anticoagulants on different bone parameters[J]. J Osteoporos,2019,2019:2069176
[20] Wen L, Chen J,Duan L, et al. Vitamin K dependent proteins involved in bone and cardiovascular health (Review)[J]. Mol Med Rep,2018,18(1):3-15.
[21] Akbari S, Rasouli-Ghahroudi AA. Vitamin K and bone metabolism:A review of the latest evidence in preclinical studies[J]. Biomed Res Int, 2018,2018:4629383.
[22] Giri TK, Newton D, Chaudhary O, et al. Maximal dose-response of vitamin-K₂ (menaquinone-4) on undercarboxylated osteocalcin in women with osteoporosis[J]. Int J Vitam Nutr Res, 2020,90(1-2):42-48.
[23] Hirota Y, Suhara Y. New aspects of vitamin K research with synthetic ligands:Transcriptional activity via SXR and neural differentiation activity[J]. Int J Mol Sci,2019,20(12):3006.
[24] 李月,刘艳,路更,等. 维生素K对CKD-MBD骨代谢异常以及血管钙化的治疗及作用机制[J]. 中国骨质疏松杂志,2022,28(2):308-312.
Li Y,Liu Y,Lu G,et al.Therapeutical action and mechanism of vitamin K in chronic kidney disease-mineral and bone disorder and vascular calcification[J].Chin J Osteoporos,2022,28(2):308-312.(in Chinese)
[25] 聂淑慧,胡贻椿,段一凡,等. 国内外维生素K研究现状及膳食参考摄入量修订进展[J]. 营养学报,2022,44(2):105-111.
Nie SH,Hu YC,Duan YF, et al.Research status of vitamin K at home and abroad and the revision progress of dietary reference intakes[J].Acta Nutrimenta Sinica,2022,44(2):105-111.(in Chinese)
[26] 赵利涛,荣雪芹,郑庆玲,等. 血清维生素K₁水平与绝经后女性腰椎骨密度相关性分析[J]. 中国骨质疏松杂志,2019,25(4):489-492.
Zhao LT,Rong XQ,Zheng QL, et al.Analysis of serum vitamin K₁ levels and bone mineral density in postmenopausal women[J].Chin J Osteoporos,2019,25(4):489-492.(in Chinese)