Research advance in the role of gut microbiota in attention deficit hyperactivity disorder

ZHENG Jie; CHEN Yanhui

doi:10.11852/zgetbjzz2022-1269

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (9) : 986-989. DOI: 10.11852/zgetbjzz2022-1269

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Research advance in the role of gut microbiota in attention deficit hyperactivity disorder

ZHENG Jie, CHEN Yanhui

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Abstract

The microbial-gut-brain axis (MGB), which is composed of gut microbiota and its metabolites together with the central nervous system, neuroendocrine system, neuroimmune system and autonomic nervous system, is considered to be a bridge between environmental risk factors and pathological mechanisms of ADHD. Monoamine neurotransmitter levels and hypothalamic-pituitary-adrenal (HPA) axis disturbances, which have received much attention in ADHD research, are closely related to MGB imbalance. Given that the differences in geographical environment and dietary habits may cause regional differences in the intestinal microbial composition, exploring the influence of living habits on the specific characteristics and metabolites of intestinal microbes in different regions and their role in the pathological process of ADHD is helpful to understand the mechanism of MGB involving in ADHD and to provide a basis for accurate ADHD prevention and treatment strategies as well as life guidance.

Key words

attention deficit hyperactivity disorder / microbiota-gut-brain axis / pathogenesis / environmental factors / biomarkers

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ZHENG Jie, CHEN Yanhui. Research advance in the role of gut microbiota in attention deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2023, 31(9): 986-989 https://doi.org/10.11852/zgetbjzz2022-1269

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