Association of perinatal ureaplasma urealyticum infection with adverse pregnancy outcomes and neonatal related disorders

LI Qiu-ping

doi:10.11852/zgetbjzz2022-1127

PDF(536 KB)

Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (10) : 1049-1052. DOI: 10.11852/zgetbjzz2022-1127

Association of perinatal ureaplasma urealyticum infection with adverse pregnancy outcomes and neonatal related disorders

LI Qiu-ping

Author information +

History +

Abstract

Perinatal ureaplasma spp. infection is associated with adverse pregnancy outcomes such as infertility, premature rupture of membranes, chorioamnionitis, miscarriage, preterm delivery and even stillbirth, as well as many diseases in neonatal period. This paper will focus on the epidemiological characteristics of ureaplasma spp. infection in perinatal period, the association of ureaplasma spp. exposure with adverse pregnancy outcomes, neonatal and especially preterm related diseases such as sepsis, bronchopulmonary dysplasia, intraventricular hemorrhage and necrotizing enterocolitis, as well as the diagnosis and prevention measures of ureaplasma spp., so as to provide reference for the prevention and treatment of clinically relevant diseases.This paper will focus on the epidemiological characteristics of perinatal Mycoplasma solani infections, the association of perinatal Mycoplasma solani exposure with adverse maternal outcomes, neonatal and especially preterm related diseases such as sepsis, bronchopulmonary dysplasia, intraventricular hemorrhage and necrotizing small bowel colitis, and the diagnostic and preventive measures of Mycoplasma solani for clinical control.

Key words

perinatal period / urealyticum species / newborn / disease

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LI Qiu-ping. Association of perinatal ureaplasma urealyticum infection with adverse pregnancy outcomes and neonatal related disorders[J]. Chinese Journal of Child Health Care. 2022, 30(10): 1049-1052 https://doi.org/10.11852/zgetbjzz2022-1127

References

[1] Kacerovsky M, Kukla R, Bolehovska R, et al. Prevalence and load of cervical ureaplasma species with respect to intra-amniotic complications in women with preterm prelabor rupture of membranes before 34 weeks[J]. Front Pharmacol,2022,13: 860498.
[2] Plummer EL, Vodstrcil LA, Bodiyabadu K, et al. Are mycoplasma hominis, ureaplasma urealyticum and ureaplasma parvum associated with specific genital symptoms and clinical signs in nonpregnant women[J]. Clin Infect Dis,2021,73(4): 659-668.
[3] Sprong KE, Mabenge M, Wright CA, et al. Ureaplasma species and preterm birth: current perspectives[J]. Crit Rev Microbiol,2020,46(2): 169-181.
[4] Xu YP, Hu JM, Huang YQ, et al. Maternal ureaplasma exposure during pregnancy and the risk of preterm birth and BPD: A Meta-analysis[J]. Arch Gynecol Obstet,2022. doi: 10.1007/s00404-022-06491-7.
[5] Chu A, de St Maurice A, Sim MS, et al. Neonatal mycoplasma and ureaplasma infections[J]. Pediatr Ann,2020,49(7): e305-e312.
[6] Silwedel C, Speer CP, Glaser K. Ureaplasma-associated prenatal, perinatal, and neonatal morbidities[J]. Expert Rev Clin Immunol,2017,13(11): 1073-1087.
[7] Gupta A, Gupta A, Gupta S, et al. Correlation of mycoplasma with unexplained infertility[J]. Arch Gynecol Obstet,2009, 280(6):981-985.
[8] Zhou YH, Ma HX, Shi XX,et al.Ureaplasma spp. in male infertility and its relationship with semen quality and seminal plasma components[J]. J Microbiol Immunol Infect,2018,51(6):778-783.
[9] Jacobsson B,Aaltonen R,Rantakokko-Jalava K,et al.Quantification of Ureaplasma urealyticum DNA in the amniotic fluid from patients in PTL and pPROM and its relation to inflammatory cytokine levels[J]. Acta Obstet Gynecol Scand,2009,88(1):63-70.
[10] Rittenschober-Böhm J, Waldhoer T, Schulz SM, et al. Vaginal Ureaplasma parvum serovars and spontaneous preterm birth[J]. Am J Obstet Gynecol,2019,220(6): 594.
[11] Miyoshi Y, Suga S, Sugimi S, et al. Vaginal Ureaplasma urealyticum or Mycoplasma hominis and preterm delivery in women with threatened preterm labor[J]. J Matern Fetal Neonatal Med, 2022,35(5):878-883..
[12] Resch B, Gutmann C, Reiterer F, et al. Neonatal Ureaplasma urealyticum colonization increases pulmonary and cerebral morbidity despite treatment with macrolide antibiotics[J]. Infection,2016, 44(3):323.
[13] Ollikainen J, Hiekkaniemi H, Korppi M, et al. Ureaplasma urealyticum infection associated with acute respiratory insufficiency and death in premature infants[J]. J Pediatr,1993,122(5 Pt 1): 756-760.
[14] Yoder BA,Coalson JJ,Winter VT,et al.Effects of antenatal colonization with ureaplasma urealyticum on pulmonary disease in the immature baboon[J]. Pediatr Res,2003 ,54(6):797-807.
[15] Sung TJ, Xiao L, Duffy L, et al. Frequency of ureaplasma serovars in respiratory secretions of preterm infants at risk for bronchopulmonary dysplasia[J]. Pediatr Infect Dis J,2011,30(5):379-383.
[16] Viscardi RM. Ureaplasma species: role in neonatal morbidities and outcomes[J]. Arch Dis Child Fetal Neonatal Ed,2014,99(1): 87-92.
[17] Schelonka RL,Katz B,Waites KB,et al.Critical appraisal of the role of Ureaplasma in the development of bronchopulmonary dysplasia with metaanalytic techniques[J]. Pediatr Infect Dis J,2005 ,24(12):1033-1039.
[18] Wang EE, Ohlsson A, Kellner JD. Association of Ureaplasma urealyticum colonization with chronic lung disease of prematurity: results of a metaanalysis[J]. J Pediatr,1995,127(4): 640-644.
[19] Lowe J, Watkins WJ, Edwards MO, et al. Association between pulmonary ureaplasma colonization and bronchopulmonary dysplasia in preterm infants: updated systematic review and meta-analysis[J]. Pediatr Infect Dis J,2014,33(7):697-702.
[20] Goldenberg RL, Andrews WW, Goepfert AR, et al. The alabama preterm birth study: Umbilical cord blood ureaplasma urealyticum and mycoplasma hominis cultures in very preterm newborn infants[J]. Am J Obstet Gynecol,2008,198(1): 43.
[21] Milisavljevic V, Garg M, Vuletic I,et al. Prospective assessment of the gastroesophageal microbiome in VLBW neonates[J]. BMC Pediatr,2013, 13:49.
[22] Wolfs TG, Kallapur SG, Knox CL, et al. Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner[J]. Mucosal Immunol, 2013,6(3): 547-556.
[23] Okogbule-Wonodi A, Gross G, Sun CC,et al. Necrotizing enterocolitis is associated with ureaplasma colonization in preterm infants[J]. Pediatr Res,2011, 69(5pt1):442-447.
[24] Viscardi R, Hashmi N, GrossG, et al. Incidence of invasive Ureaplasma in VLBW infants: relationship to severe intraventricular hemorrhage[J]. J Perinatol,2008,28(11): 759-765.
[25] Kasper DC, Mechtler TP, Böhm J, et al. In utero exposure to Ureaplasma spp. is associated with increased rate of bronchopulmonary dysplasia and intraventricular hemorrhage in preterm infants[J]. J Perinat Med,2011,39(3):331-336.
[26] Viscardi RM. Ureaplasma species: role in diseases of prematurity[J]. Clin Perinatol,2010,37(2): 393-409.
[27] Berger A, Witt A, Haiden N, et al. Intrauterine infection with Ureaplasma species is associated with adverse neuromotor outcome at 1 and 2 years adjusted age in preterm infants[J]. J Perinat Med,2009,37(1):72-78.
[28] Shrivastava S, Methé BA, Inman J, et al. Comparative genome analysis of 19 Ureaplasma urealyticum and Ureaplasma parvum strains[J]. BMC Microbiol,2012, 12:88.
[29] Donders GGG, Ruban K, Bellen G, et al. Mycoplasma/ureaplasma infection in pregnancy:To screen or not to screen[J]. J Perinat Med,2017,45(5):505-515.
[30] Grigsby PL, Novy MJ, Sadowsky DW, et al. Maternal azithromycin therapy for Ureaplasma intraamniotic infection delays preterm delivery and reduces fetal lung injury in a primate model[J]. Am J Obstet Gynecol,2012,207(6): 475.
[31] Viscardi RM, Terrin ML, Magder LS, et al. Randomised trial of azithromycin to eradicate Ureaplasma in preterm infants[J]. Arch Dis Child Fetal Neonatal Ed,2020, 105(6): 615-622.
[32] Viscardi RM,Terrin ML,Magder LS,et al. Randomized trial of azithromycin to eradicate Ureaplasma respiratory colonization in preterm infants: 2-year outcomes[J]. Pediatric Res, 2022,91(1):178-187.