Associations between febrile seizures and frequent nocturnal enuresis in children

MAO Yi; SHEN Jia-yao; ZHONG Shao-gen; JIN Xing-ming; MA Jun

doi:10.11852/zgetbjzz2022-1022

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (2) : 147-151. DOI: 10.11852/zgetbjzz2022-1022

Original Articles

Associations between febrile seizures and frequent nocturnal enuresis in children

MAO Yi¹, SHEN Jia-yao², ZHONG Shao-gen¹, JIN Xing-ming¹, MA Jun¹

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Abstract

Objective To investigate the associations between febrile seizures and frequent nocturnal enuresis, so as to provide evidence for study of risk factors for enuresis and explore the changes of the associations in different ages and genders. Methods A stratified cluster random sampling method was used to select 85 860 children aged 5 to 12 years in 3 urban areas and 4 suburbs in Shanghai from June 2014 to June 2015, and children were asked to fill out questionnaire. Multivariate Logistic regression analysis was used to analyze the association between febrile seizures and frequent nocturnal enuresis. Sensitivity analysis was performed to observe the changes of association in ages and genders. Results Finally 62 290 valid questionnaires were enrolled in this study. Multivariate analysis showed that children with febrile seizures still had a high risk of enuresis after controlling for confounding factors (OR=7.740, 95%CI:5.512 - 10.870, P<0.001). In addition, the association between the two increased with ages (P<0.001), which was more significant in girls (OR=13.798, 95%CI:8.056 - 23.631, P<0.001) than boys (OR=4.422, 95%CI:2.580 - 7.579, P<0.001). Conclusion Febrile seizures is significantly associated with frequent nocturnal enuresis, especially in older age groups and girls, suggesting that FS is one of the risk factors for frequent nocturnal enuresis.

Key words

frequent nocturnal enuresis / febrile seizures / children / risk factors / gender

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MAO Yi, SHEN Jia-yao, ZHONG Shao-gen, JIN Xing-ming, MA Jun. Associations between febrile seizures and frequent nocturnal enuresis in children[J]. Chinese Journal of Child Health Care. 2023, 31(2): 147-151 https://doi.org/10.11852/zgetbjzz2022-1022

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