Changes and clinical significance of serum 25-(OH)D3 and vitamin D-binding protein levels in adolescent patients with first-episode depressive disorder

YANG Liu; LIU Yushan; WU Ningbo; SUN Jing

doi:10.11852/zgetbjzz2022-0902

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (3) : 259-262. DOI: 10.11852/zgetbjzz2022-0902

Changes and clinical significance of serum 25-(OH)D₃ and vitamin D-binding protein levels in adolescent patients with first-episode depressive disorder

YANG Liu, LIU Yushan, WU Ningbo, SUN Jing

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Abstract

Objective To test the levels of serum 25-hydroxyvitamin D₃[25-(OH)D₃] and vitamin D-binding protein (VDBP) in adolescent patients with first-episode depressive disorder, and to analyze their clinical significance. Method A total of 100 adolescent patients with first-episode depressive disorder admitted to Qinhuangdao First Hospital from April 2021 to March 2022 were selected as the depression group, and 100 healthy adolescents who took physical examinations during the same period were selected as the control group. The levels of serum 25-(OH)D₃ and VDBP were detected by enzyme-linked immunosorbent assay. Hamilton Depression Scale (HAMD) was used to assess the degree of depression in patients with depression, and then the adolescents were divided into mild group (n=41), moderate group (n=32) and severe group (n=27). The levels of serum 25-(OH)D₃ and VDBP among depression group, control group and adolescent patients with first-episode depressive disorder with different degrees of depression were compared. The correlation of serum 25-(OH)D₃ and VDBP levels with HAMD score in adolescent patients with first-episode depressive disorder and the influencing factors of the occurrence of first-episode depressive disorder were analyzed. Results Compared with the control group, the level of serum 25-(OH)D₃ in the depression group decreased (t=10.625, P<0.05), while the level of VDBP increased (t=13.158, P<0.05). The level of serum 25-(OH)D₃ of children in mild, moderate and severe depression group decreased in turn (t=58.319, P<0.05), while the level of VDBP increased in turn (F=18.805, P<0.05). Serum 25-(OH)D₃ level was negatively correlated with HAMD score and VDBP in adolescent patients with first-episode depressive disorder (r=-0.517, -0.511, P<0.05), while serum VDBP level was positively correlated with HAMD score (r=0.498, P<0.05). Serum 25-(OH)D₃ deficiency(OR=1.775) and high level of VDBP (OR=1.519) were risk factors for the occurrence of first-episode depressive disorder (P<0.05). Conclusions The serum 25-(OH)D₃ level is lower in the adolescent patients with first-episode depressive disorder, and the VDBP level is higher.Serum 25-(OH)D₃level is negatively correlated with VDBP, both of which were significantly correlated with HAMD scores. Both VDBP and 25-(OH)D₃ can be used as auxiliary indicators to determine the severity of adolescent depression.

Key words

adolescent patients with first-episode depressive disorder / 25-(OH)D₃ / vitamin D-binding protein / Hamilton Depression Scale

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YANG Liu, LIU Yushan, WU Ningbo, SUN Jing. Changes and clinical significance of serum 25-(OH)D₃ and vitamin D-binding protein levels in adolescent patients with first-episode depressive disorder[J]. Chinese Journal of Child Health Care. 2023, 31(3): 259-262 https://doi.org/10.11852/zgetbjzz2022-0902

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