Cohort study of allergic exposure at different time points and  neuropsychological development in children

WENG Ting-ting; GAO Guo-peng; WANG Qiong-yao; XIE Liang-liang; LI Chun-gang; YAN Shuang-qin; TAO Fang-biao

doi:10.11852/zgetbjzz2022-0870

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (2) : 126-130. DOI: 10.11852/zgetbjzz2022-0870

Original Articles

Cohort study of allergic exposure at different time points and neuropsychological development in children

WENG Ting-ting¹, GAO Guo-peng¹, WANG Qiong-yao¹, XIE Liang-liang¹, LI Chun-gang², YAN Shuang-qin¹, TAO Fang-biao²

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Abstract

Objective To describe the incidence of allergies in different periods of early childhood, and to analyze the correlation between anaphylactic diseases and children′s neurodevelopment in prenatal and childhood. Methods During February 2015 to August 2016, 2 212 pregnant women who had their first antenatal examination at Ma′anshan Maternity and Child Health Hospital were recruited in this cohort, and were followed up until children were 36 months old. Information of allergy in prenatal and early childhood was collected by filling out questionnaires. The Ages and Stages questionnaire (ASQ) was used to evaluate 36-month-old children′s neurodevelopment including communication (CM), fine motion (FM), gross motion (GM), problem-solving (CG) and personal-social (PS) development. Both "near the threshold" and "below the threshold" were defined as abnormal development. Results Finally 1 742 children completed survey at 36 months old, of whom 52.0% were boys and 48.0% were girls. The incidences of allergic diseases in mothers before and during pregnancy were 22.6% (480/2 120) and 13.5% (254/1 882), respectively. The incidences of allergic and in infants at the age of 3, 12 and 24 months were 36.0% (713/1 981), 26.0% (472/1 816) and 22.3% (352/1 581), respectively. Univariate analysis showed that there was only significant difference in ASQ results in children whose mother had pre-pregnancy allergy or not. There was a significantly positive correlation between maternal pre-pregnancy allergy and abnormal development of fine motor at 36 months old. After adjusting gender, only child or not, family incomes and maternal age, the correlation was still statistically significant (aOR=1.89, 95%CI: 1.04 - 3.42). Conclusions Allergy is common in both prenatal period and early childhood. Attention should be paid to the potential harmful effects of maternal allergy on children′s neurodevelopment, and further researches on the mechanism are warranted.

Key words

allergy / immunology / child neuropsychological development / prospective study

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WENG Ting-ting, GAO Guo-peng, WANG Qiong-yao, XIE Liang-liang, LI Chun-gang, YAN Shuang-qin, TAO Fang-biao. Cohort study of allergic exposure at different time points and neuropsychological development in children[J]. Chinese Journal of Child Health Care. 2023, 31(2): 126-130 https://doi.org/10.11852/zgetbjzz2022-0870

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