Molecular genetic characteristics of growth plate regulation and physical development disorder

HE Xi-yu; HE Xiu-mei

doi:10.11852/zgetbjzz2022-0852

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (9) : 929-932. DOI: 10.11852/zgetbjzz2022-0852

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Molecular genetic characteristics of growth plate regulation and physical development disorder

HE Xi-yu, HE Xiu-mei

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Abstract

The linear growth of children's physique is realized by the proliferation and differentiation of growth plate chondrocytes. The function of growth plate chondrocytes is controlled by intracellular signal pathway, extracellular matrix, growth hormone-insulin-like growth factor axis, secretion factors beside growth plate and external factors (nutritional intake, inflammatory factors). Adult height has great heterogeneity, which is mainly determined by genetic factors and involves multiple functional genes. Growth-related gene variation leads to abnormal differentiation and proliferation of growth plate chondrocytes, which is the genetic and pathological mechanism of children's growth disorders, showing a wide spectrum of clinical manifestations. Understanding the genetic causes and mechanisms of physical development disorders can provide help for precise treatment.

Key words

growth disorder / growth plate / genetic variation / inheritance

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HE Xi-yu, HE Xiu-mei. Molecular genetic characteristics of growth plate regulation and physical development disorder[J]. Chinese Journal of Child Health Care. 2022, 30(9): 929-932 https://doi.org/10.11852/zgetbjzz2022-0852

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