Comparison of clinical application between Autism Diagnostic Observation Schedule Second Edition Module-1 and Children Autism Rating Scale in children with autism spectrum disorder

WU Man-hong; XU Ning; CHANG Yan-qun; WEN Jian; LOU Yu-yan; HUANG Shuang-miao

doi:10.11852/zgetbjzz2022-0613

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (11) : 1181-1184. DOI: 10.11852/zgetbjzz2022-0613

Comparison of clinical application between Autism Diagnostic Observation Schedule Second Edition Module-1 and Children Autism Rating Scale in children with autism spectrum disorder

WU Man-hong, XU Ning, CHANG Yan-qun, WEN Jian, LOU Yu-yan, HUANG Shuang-miao

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Abstract

Objective To compare the diagnostic value between Autism Diagnostic Observation Schedule Second Edition(ADOS-2) Module-1 and Children Autism Rating Scale (CARS) for children with autism spectrum disorder (ASD), in order to provide reference for clinical application. Methods From January 2019 to March 2022, a total of 104 children who firstly visited and diagnosed in the Department of Neurological Rehabilitation, Guangdong Women and Children Hospital were enrolled in this study, including 60 ASD children (ASD group:30 cases of high function and 30 cases of low function,), 24 children with global developmental delay (GDD) and 20 normal children (non-ASD group). All children were assessed by ADOS-2 Module-1 and CARS. The consistency of diagnostic results between the two scales and the criteria of American Diagnostic and Statistical Manual of Mental Disorders-5(DSM-5) was evaluated, and the sensitivity and specificityof the two scales in the diagnosis of ASD were compared. Results 1) The consistency between ADOS-2 module 1 and DSM-5 was good (Kappa=0.862),as well as between ADOS-2 module 1 and CARS (Kappa=0.695).The consistency was medium between CARS and DSM-5 (Kappa=0.509), 2) The sensitivity of ADOS-2 module 1 was significantly better than that of CARS (χ²=13.333, P<0.001). There was no significant difference in the sensitivity and specificity between diagnosing children with IQ≥70 and children with IQ <70(P>0.05). The sensitivity of CARS in the diagnosis of children with IQ <70 was significantly better than that of children with IQ≥70 (χ²=7.500, P=0.006), but the specificity was not statistically significant (P>0.05). Conclusions ADOS-2 module-1 and CARS are both important tools to assist in the diagnosis of ASD, and ADOS-2 module-1 has higher sensitivity and specificity in the early diagnosis of ASD children. In clinical work, it is recommended to lower the diagnostic threshold of CARS for children with IQ ≥ 70 in order to improve the diagnostic sensitivity of CARS and reduce the rate of missed diagnosis.

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autism / Autism Diagnostic Observation Schedule / Children Autism Rating Scale

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WU Man-hong, XU Ning, CHANG Yan-qun, WEN Jian, LOU Yu-yan, HUANG Shuang-miao. Comparison of clinical application between Autism Diagnostic Observation Schedule Second Edition Module-1 and Children Autism Rating Scale in children with autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2022, 30(11): 1181-1184 https://doi.org/10.11852/zgetbjzz2022-0613

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