Novel regulators of growth plate development

ZHANG Su-ping; CHEN Hong; CHEN Rui-min

doi:10.11852/zgetbjzz2022-0553

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (9) : 981-984. DOI: 10.11852/zgetbjzz2022-0553

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Novel regulators of growth plate development

ZHANG Su-ping, CHEN Hong, CHEN Rui-min

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Abstract

The metaphyseal growth plate of long bones is the structural basis for linear growth and is a dynamic, highly differentiated cartilaginous structure. The proliferation, differentiation, hypertrophy and extracellular matrix formation of chondrocytes are the keys to growth plate development and linear growth. Abnormal growth plate development will lead to short stature, and its mechanism is complex. A variety of regulators regulate growth plate development through different mechanisms. In addition to the classic genes SOX9, ACAN, and RUNX2, in recent years, with the development of genetic testing technology, more pathogenic genes have been discovered. The new regulators are involved in a variety of biological processes, including the extracellular skeleton, intracellular signal transduction, ribosome transcriptional processing, protein ubiquitination modification, and epigenetic modification, enriching the gene regulatory network of short stature. This article reviews the roles of some novel regulatory factors in growth plate development.

Key words

growth plate / short stature / gene / novel regulation

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ZHANG Su-ping, CHEN Hong, CHEN Rui-min. Novel regulators of growth plate development[J]. Chinese Journal of Child Health Care. 2022, 30(9): 981-984 https://doi.org/10.11852/zgetbjzz2022-0553

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