Association of different status of iron and anemia with neurobehavioral development in children aged 6 to 24 months

ZHENG Juan; LIU Jie; YANG Wen-han

doi:10.11852/zgetbjzz2022-0413

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (7) : 725-730. DOI: 10.11852/zgetbjzz2022-0413

Association of different status of iron and anemia with neurobehavioral development in children aged 6 to 24 months

ZHENG Juan^*, LIU Jie, YANG Wen-han

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Abstract

Objective To explore the association of different status of iron and anemia with neurobehavioral development in children aged 6 to 24 months, so as to provide suggestions for early intervention of children with neurobehavioral development deviation. Methods A total of 322 children aged 6 to 24 months, who underwent physical examination in Department of Child Health, Maternity and Child Health Hospital of Baiyun District, Guangzhou from January 1st to December 31st, 2020, were selected into this cross-sectional study voluntarily. Blood routine, serum ferritin, C-reactive protein and α-1-acid glycoprotein test for the venous blood were used to determine the status of iron and anemia. The neurobehavioral development was assessed by the China Developmental Scale for Children aged 0 to 6 years. Results The prevalence rates of anemia and iron deficiency in children aged 6 to 24 months were 8.07% and 11.49%, respectively. Iron deficiency anemia was negatively correlated with the development of gross motor(β=-6.70, 95%CI:-12.84 --0.56), fine motor(β=-6.27, 95%CI:-11.87 - -0.68) and adaptive ability(β=-6.19, 95%CI:-11.91 - -0.47) of children aged 6 to 24 months. There was a negative correlation between iron deficiency with no-anemia and the development of fine motor(β=-1.65, 95%CI:-3.19 - -0.10) and adaptive ability(β=-2.24, 95%CI:-3.86 - -0.63) of children aged 6 to 24 months. Non-iron-deficiency anemia was negatively related to the development of gross motor(β=-1.52, 95%CI:-2.92 - -0.16), fine motor(β=-1.46, 95%CI:-2.70 - -0.23) and adaptive ability(β=-1.39, 95%CI:-2.68 - -0.11) of children aged 6 to 24 months. Conclusions Both iron deficiency and anemia are negatively correlated with the neurobehavioral development of children aged 6~24 months, which may have adverse effects, and its mechanism needs to be further explored.

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iron deficiency / anemia / children / neurobehavioral development

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ZHENG Juan, LIU Jie, YANG Wen-han. Association of different status of iron and anemia with neurobehavioral development in children aged 6 to 24 months[J]. Chinese Journal of Child Health Care. 2022, 30(7): 725-730 https://doi.org/10.11852/zgetbjzz2022-0413

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