Meta-analysis of the risk factors for recurrent wheezing after bronchiolitis

WANG Xu; WANG Shu-ying; LI Li; ZOU Ying-xue

doi:10.11852/zgetbjzz2022-0313

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (2) : 190-194. DOI: 10.11852/zgetbjzz2022-0313

Meta Analysis

Meta-analysis of the risk factors for recurrent wheezing after bronchiolitis

WANG Xu^1,2, WANG Shu-ying³, LI Li^1,2, ZOU Ying-xue¹

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Abstract

Objective To systematically analyze the risk factors of recurring wheezing after bronchiolitis, in order to provide reference for reducing wheezing. Methods CNKI, Wanfang Data, Chinese biomedical literature database, VIP, Web of science, PubMed, Cochrane and Embase were searched until November 2021. The Chinese search term included bronchiolitis, wheezing and risk factors, the English search terms were bronchiolitis, bronchiolitides, respiratory sound, wheezing, stridor and risk factors. Two researchers both read and evaluated the documents individually. Data was extracted by researchers using RevMan 5.3 software. Meta-analysis was then performed with RevMan5.3 software. Results Totally 13 studies were finally included, of which six studies were in Chinese and seven studies in English. Meta-analysis results showed that the main risk factors for recurrent wheezing after bronchiolitis included boys (OR=1.26,95%CI:1.04 - 1.54), a history of eczema (OR=2.68, 95%CI:2.02 - 3.56), personal history of allergy (OR=4.42, 95%CI:3.31 - 5.91), family history of asthma (OR=3.72, 95%CI: 2.38 - 5.83), family history of atopic disease (OR=2.75, 95%CI: 1.50 - 5.04) and tobacco exposure (OR=2.68, 95%CI:1.44-4.99),while breastfeeding was a protective factor (OR=0.47, 95%CI:0.23 - 0.96). Conclusions There are lots of risk factors for recurrent wheezing after bronchiolitis in children, among which the leading risk factor is personal history of allergy, followed by family history of asthma, family history of atopic disease, history of eczema, tobacco exposure, boys, while breastfeeding may reduce the prevalence of recurrent wheezing after bronchiolitis.

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bronchiolitis / wheezing / Meta-analysis / risk factors

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WANG Xu, WANG Shu-ying, LI Li, ZOU Ying-xue. Meta-analysis of the risk factors for recurrent wheezing after bronchiolitis[J]. Chinese Journal of Child Health Care. 2023, 31(2): 190-194 https://doi.org/10.11852/zgetbjzz2022-0313

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