Meta-analysis of the efficacy of parent-mediated intervention in the treatment of autism spectrum disorder

LIN Huanxi; LIU Panting; TONG Meiling; CHI Xia; QIAN Jun; HONG Qin

doi:10.11852/zgetbjzz2022-0266

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (3) : 304-310. DOI: 10.11852/zgetbjzz2022-0266

Meta Analysis

Meta-analysis of the efficacy of parent-mediated intervention in the treatment of autism spectrum disorder

LIN Huanxi^1,2, LIU Panting^1,2, TONG Meiling², CHI Xia², QIAN Jun², HONG Qin²

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Abstract

Objective To evaluate the efficay of parent-mediated intervention on the improvement of symptoms of children with autism spectrum disorder (ASD), in order to provide theoretical basis for the treatment and intervention of ASD children. Method Randomized controlled trials regarding the effects of parent-mediated intervention on ASD children were searched in eight databases, including PubMed, Embase, Web of Science, CINAHL, cnki, Wanfang, VIP and Sinomed. RevMan 5.3 software was used for statistical analysis and the Cochrane collaboration tool was used to evaluate the quality of the literature. Results A total of 1 299 ASD children from 17 randomized controlled trials (RCTs) were included in this study. Meta-analysis results showed that significant improvement was observed in core symptoms of ASD children with parent-mediated intervention, including social interaction (SMD=0.34, 95%CI: 0.16 - 0.52, P＜0.05), adaptive behavior (MD=5.48, 95%CI:2.44 - 8.52, P<0.001), shared or joint attention(SMD=0.31, 95%CI:0.05 - 0.56, P＜0.05) and the severity of autism (SMD=-0.93, 95%CI:-1.10 - -0.77, P＜0.001), but expressive language, receptive language and stereotyped behaviors had no significant improvement. After intervention, parents' stress was significantly reduced (SMD=-0.30, 95%CI:-0.54 - -0.07,P=0.01). Conclusion Parent-mediated interventions have a beneficial effect on symptoms improvement and parental stress reduction in ASD children, but high quality research is warranted to confirm the conclusion further.

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autism spectrum disorder / early intervention / parents / Meta-analysis

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LIN Huanxi, LIU Panting, TONG Meiling, CHI Xia, QIAN Jun, HONG Qin. Meta-analysis of the efficacy of parent-mediated intervention in the treatment of autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2023, 31(3): 304-310 https://doi.org/10.11852/zgetbjzz2022-0266

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