Meta-analysis of the relationship between serum vitamin D level and risk of pediatric fractures

YE Xixia; ZHU Zhixin; CHEN Mingming; ZHANG Yaqin; ZHOU Jing; CAO Wenting

doi:10.11852/zgetbjzz2022-0240

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Chinese Journal of Child Health Care ›› 2023, Vol. 31 ›› Issue (4) : 416-421. DOI: 10.11852/zgetbjzz2022-0240

Meta Analysis

Meta-analysis of the relationship between serum vitamin D level and risk of pediatric fractures

YE Xixia¹, ZHU Zhixin², CHEN Mingming², ZHANG Yaqin¹, ZHOU Jing², CAO Wenting^1,2

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Abstract

Objective To systematically evaluate the correlation between serum vitamin D level and the fracture risk in children and adolescents, so as to provide theoretical basis for early prevention of fractures in children. Methods PubMed, Embase, CNKI,VIP and Wangfang Database were searched to retrieve the observational studies on the association between serum vitamin D level and the fracture risk from the establishment of the database to December 31st 2021. Simultaneously, references of related literature were searched. The quality of the literature was evaluated by NOS standard application. Review Manager 5.4 software was used to perform Meta-analysis, the MD value of the combined effect size and its 95% confidence interval(CI) were estimated. Results A total of 18 English articles were included, with 2 614 cases in the fracture group and 4 519 in the control group. Meta-analysis showed that serum Vit D level in the fracture group was significantly lower than that in the control group(MD=-3.54, 95%CI:-5.45 - -1.63, P<0.05). Subgroup analysis showed that the serum Vit D level of Asian children in the fracture group was significantly lower than that in the control group(MD=-5.15, 95%CI:-9.40 - -0.91, P<0.05). Conclusion Lower serum vitamin D level in children with fracture is associated with an increased risk of fracture in children.

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adolescent / children / fracture / vitamin D / Meta-analysis

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YE Xixia, ZHU Zhixin, CHEN Mingming, ZHANG Yaqin, ZHOU Jing, CAO Wenting. Meta-analysis of the relationship between serum vitamin D level and risk of pediatric fractures[J]. Chinese Journal of Child Health Care. 2023, 31(4): 416-421 https://doi.org/10.11852/zgetbjzz2022-0240

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