Objective To investigate the correlation of calcium and vitamin D levels with body length development of 2- to 3-year-old children, so as to provide theoretical basis for the intervention of physical development deviation. Methods A retrospective analysis was performed on the clinical data of 204 children aged 2 to 3 years who underwent routine physical examination in the Department of Child Health of Northwest Women and Children's Hospital from September 2019 to June 2021.Standard physical measurements and previous calcium and vitamin D supplementation were collected retrospectively in the form of a questionnaire, and serum 25-(OH) D level and bone mineral density were measured. Spearman correlation and Logistic multifactor regression analysis were used to analyze the correlation of calcium and vitamin D levels with physical development. Results The median daily dose of vitamin D supplementation was 569.5 U, and the median of serum 25-(OH)D was 35.60 ng/dl in 204 children. The deficiency, insufficiency, sufficiency rates of vitamin D were 1.96%, 0.98% and 97.06%, respectively. No children took in excessive vitamin D. The median bone mineral density(BMD) was P64.0. Univariate Spearman rank correlation analysis indicated that the daily average supplementation doses of vitamin D and calcium were both positively correlated with body length(r=0.172, 0.213, P<0.05), while the bone mineral density was negatively correlated with body length(r=-0.138, P<0.05). Multivariate Logistic regression analysis showed that the average daily calcium supplementation dose was positively correlated with body length, with statistical significance(OR=1.003, 95%CI:1.001 - 1.006, P<0.05), while daily vitamin D supplementation dose and bone mineral density were not found to be significantly related to body length. Conclusion Continuous supplementation of calcium can promote the body length development of 2- to 3-year-old children.
Key words
calcium /
body length /
25-hydroxyl vitamin D /
bone mineral density
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 武华红,李阳,李辉. 婴幼儿生长迟缓的研究进展[J].中国儿童保健杂志, 2021,29(10):1105-1108.
[2] 中华预防医学会儿童保健分会.中国儿童钙营养专家共识[J].中国儿童保健杂志,2019,30(3):262-269.
[3] 申昆玲,李廷玉.儿童维生素D和钙缺乏相关疾病[M].北京:人民卫生出版社,2016:162-163.
[4] Munns CF, Shaw N, Kiely M,et al. Global consensus recommendations on prevention and management of nutritional rickets[J].Clin Endocrinol Metab,2016,101(2):394-415.
[5] 张亚钦,李辉,武华红,等.中国九市7岁以下儿童生长迟缓状况调查研究[J].中华儿科杂志,2020,58(3):194-200.
[6] 尼玛曲措,薛姣姣,花地敏,等.西藏0~5岁儿童母乳喂养时间与生长迟缓的关联研究[J]. 现代预防医学,2021,48(9):1572-1575.
[7] Koyama S, Kubota T, Naganuma J,et al. Incidence rate of vitamin D deficiency and FGF23 levels in 12- to 13-year-old adolescents in Japan[J]. Bone Miner, 2021,39(3):456-462.
[8] 袁春彦,白冬梅,唐斌.维生素D营养状况与儿童身高发育的相关性分析[J].现代诊断与治疗,2020,31(3):382-384.
[9] Mortensen C, Mølgaard C, Hauger H, et al. Winter vitamin D3 supplementation does not increase muscle strength, but modulates the IGF-axis in young children[J]. Eur J Nutr, 2019,58(3):1183-1192.
[10] Klatka M, Partyka M, Polak A, et al. calcium and phosphorus status in children with short stature - effect of growth hormone therapy[J]. Ann Agric Environ Med,2021,28(4):686-691.
[11] Esposito S, Leonardi A, Lanciotti L, et al. Vitamin D and growth hormone in children:A review of the current scientific knowledge[J]. J Transl Med,2019,17(1):87.
[12] Abrams SA, Griffin IJ, Hawthorne KM, et al.Height and Hight Z-Score are related to calcium absorption in fifteen-year-old girls[J].Clin Endocr Metab,2005,90(9):5077-5081.
[13] Setiawan EA, Rianda D, Kadim M,et al. Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence[J]. Sci Rep, 2021,11(1):11860.
[14] 姬巧云,吴康敏,安珍,等,成都市郊区学龄前儿童钙营养状况及补钙效果的初步研究[J].中国骨质疏松杂志,2002,8(2):148-150.
[15] Kim K, Melough MM, Kim D,et al. Nutritional adequacy and diet quality are associated with standardized height-for-age among U.S. children[J]. Nutrients, 2021,13(5):1689.
PDF(482 KB)
