Objective To investigate the correlation between head circumference and neurobehavioral development of low birth weight(LBW) infants 18-month in Shanghai, so as to provide evidence for early recognition of LBW neurobehavioral retardation. Methods A prospective cohort study was conducted. Children registered and managed in Maternal and Child Health Care Hospitals of 16 districts in Shanghai from March 2016 to October 2018 were selected into this study. Questionnaire survey, head circumference measurement and Gesell developmental diagnosis were conducted on the enrolled subjects. Results A total of 758 LBW infants [329 boys(43.4%) and 429 girls(56.6%)] were included in this study, with an average birth weight of (2 223±231.13)g and an average gestational age of(35.78±1.92) weeks. Logistic regression analysis showed that the risk of abnormal development in LBW fine motor significantly increased in (head circumference-for-age Z-score,HCZ)1-month, HCZ3-month,HCZ6-month<-1 groups(OR=6.97, 3.07, 2.96, P<0.05). The risk of abnormal development in LBW adaptive behavior significantly increased in HCZ <-1 group at all follow-up months(OR=3.39, 3.28, 2.65, 3.25, 3.29, 2.67, P<0.05). The risk of abnormal development in LBW language significantly increased in HCZ1-month, HCZ3-month,HCZ6-month, HCZ9-month, HCZ12-month<-1 groups(OR=4.28, 3.32, 2.62, 3.95, 2.90, P<0.05). Multiple linear regression analysis showed that HCZ1-month was a good predictor to the dysplasia of LBW fine motor and language, and HCZ6-month could predict the dysplasia of LBW adaptive behavior to a certain extent(R2=0.052, 0.063, 0.046). Standardized regression coefficients showed that HCZ had significant contribution to the prediction of abnormal language development at each follow-up month(β=0.180, 0.165, 0.158, 0.139, 0.136, 0.113). Conclusions Head circumference has a predictive effect on the outcome of neurobehavioral development of low birth weight infants within 18 months old. Focusing on the follow-up of head circumference in LBW is important for early identification and intervention of neurobehavioral developmental delay.
Key words
low birth weight infants /
head circumference /
neurobehavioral development
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