Objective To study the correlation between new anthropometric indicators and childhood obesity with nonalcoholic fatty liver (NAFL), and to explore the cut-off point value of anthropometric indicators in screening NAFL. Methods A total of 94 obese children were selected from the Pediatric Endocrine Clinic of the Second Affiliated Hospital of Xi'an Jiaotong University from June 2018 to December 2019, and were further divided into obesity with NAFL(n=59) and obesity without NAFL(n=35). Meanwhile, 52 normal children is control group. Both groups were measured height(H), weight (W), waist circumference (WC), hip circumference (HC). serum levels of triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were tested. And abdominal ultrasound examination was conducted in all participants. Furthermore, the body mass index (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), abdominal volume index (AVI), lipid accumulation product (LAP) and visceral adiposity index (VAI) and other indicators were calculated. The tangent point value was determined by drawing the receiver operating characteristic (ROC) curve of the anthropometric index and comparing the area under curve (AUC) of each anthropometric index. Results BMI, WC, WHR, WHtR, AVI, LAP, VAI and TG of the obesity group were significantly higher than those of the control group (t=23.090, 21.068, 12.547, 22.855, 17.578, 8.159, 5.394, 6.183, P<0.001). Children in the obesity with NAFL group has higher BMI, WC, AVI, LAP and VAI than those in obesity without NAFL group (t=2.180, 2.389, 2.362, 3.643, 2.839, P<0.05). Taking obesity with or without NAFL as the dependent variable, ROC curves of BMI, WC, AVI, LAP, and VAI were drawn, respectively. The area under the ROC curve from large to small was as follows:LAP, VAI, WC, AVI and BMI. The areas under the LAP+AVI curve, AVI+VAI curve and BMI+WC curves were 0.706 (95%CI:0.595 - 0.817, P<0.001), 0.685(95%CI:0.570 - 0.800, P<0.01) and 0.652, (95%CI:0.537 - 0.768, P<0.05), respectively. The area under the ROC curve of the combined indicator from large to small was ranked as LAP+AVI, AVI+VAI, BMI+WC. Conclusion LAP combined with AVI can better screen childhood obesity with NAFL.
Key words
childhood obesity /
abdominal volume index;lipid accumulation product /
visceral adiposity index /
nonalcoholic fatty liver
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