Objective To explore the effect of early start denver model (ESDM) on toddlers with autism spectrum disorder (ASD), in order to provide evidence for improving the prognosis of ASD. Methods A total of 60 ASD toddlers were recruited from June 2015 to June 2017 in Child Developmental & Behavioral Center, the Third Affiliated Hospital of Sun Yat-sen University,and were randomly divided into experimental group (n=30) and control group (n=30).Children in experimental group received ESDM intervention, while the control group was in the period of waiting for intervention.The ESDM intervention lasted one hour once a week for 24 weeks.Baseline system assessments were conducted before intervention, PEP-3 and Gesell Development Scale (GDS) were completed in both two groups after intervention. Results Before intervention, there were no statistically significant differences in age, gender, communication, social interaction, repetitive and stereotyped behavior, cognition, language and fine movements between the experimental group and control group (P >0.05).Compared with control group, language and personal-social scores in ESDM group were significantly improved (t=2.215, 2.379, P＜0.05).Furthermore, the raw score of cognition, language expression, language understanding, small muscles, imitation and non-language behavioral characteristics in ESDM group was significantly improved (t=2.336, 2.510, 2.416, 2.578, 2.017, 2.150, P<0.05).In addition, the score gaps of languagedevelopment quotient of GDS in the ESDM group were significantly higher than those in the control group before and after intervention (Z=2.105, P<0.05). Conclusions After ESDM intervention, the language and social communication, cognitive, verbal expression and comprehension, fine movements and imitation abilities of ASD toddlers are significantly improved. Additionally, non-verbal stereotypical behaviors significantly reduce in ASD toddlers.
Key words
autism spectrum disorder /
early start denver model /
intervention /
infants and toddlers
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