Objective To analyze the effects of nasal hormones and montelukast sodium in the treatment of children with adenoid hypertrophy on sleep quality and clinical efficacy, so as to provide reference for clinical diagnosis and treatment. Methods A total of 400 cases of children with adenoid hypertrophy admitted to the Department of Otolaryngology, the Fourth Hospital of Xi'an from December 2019 to December 2020 were selected into this study, and were randomly divided into two groups according to the random number table method, with 200 cases in each group. The control group was treated with nasal hormones, and the observation group received nasal hormones and montelukast sodium treatment. The clinical efficacy, sleep quality of the two groups were observed in 8 weeks. Results After 8 weeks of treatment, the total effective rate of children in the observation group was significantly higher than that in the control group (92.5% vs. 85.00%, χ2=5.634,P<0.05). The score of sleep disorder was 5.17±1.05 and the A/N value was 0.60±0.05, significantly lower than those of the control group (6.60±1.38, 0.70±0.06, t=11.662, 18.107, P<0.05). Moreover, serum levels of IL-6, IL-4 and IL-1β, the EOS count,the expression levels of sIgE andeosinophil cationic protein(ECP) were significantly lower than those of the control group (t=30.936, 13.248, 19.718, 23.190, 10.304, 39.316, P<0.05). Conclusion The combination of nasal hormone and montelukast sodium has a significant effect in children with adenoid hypertrophy, which helps to improve the sleep quality and curative effect of children, and is worth in promoting clinically.
Key words
nasal hormones /
montelukast sodium /
adenoid hypertrophy /
sleep quality /
serum inflammatory factors /
serum allergy
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