Meta-analysis of the prevalence of non-alcoholic fatty liver disease in Chinese children

WANG Yu; YANG Zhi-ran; CHEN Run-hua

doi:10.11852/zgetbjzz2021-1338

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (7) : 764-769. DOI: 10.11852/zgetbjzz2021-1338

Meta Analysis

Meta-analysis of the prevalence of non-alcoholic fatty liver disease in Chinese children

WANG Yu^*, YANG Zhi-ran, CHEN Run-hua

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Abstract

Objective To systematically evaluate the prevalence of non-alcoholic fatty liver disease (NAFLD) in Chinese children and obese children, so as to provide basis for epidemiological studies and clinical prevention and treatment of NAFLD. Methods CNKI, VIP, WanFang Data, CBM, PubMed, Cochrane Library, Embase and Web of Science were searched to collect studies on the prevalence of NAFLD in Chinese children and obese children from 2000 to 2021 in home and abroad.Meta-analysis was performed using R language (version 4.0.5).Random effect model was used to merge data, funnel plot, Egger's test and Begg's test were used to evaluate the risk of bias. Results A total of 25 studies were included, including 8 studies on the prevalence of NAFLD in children, and 17 studies on the prevalence of NAFLD in obese children.The total sample size of the study was 35 300, and the sample size of obese children was 7 649.Meta-analysis showed that the prevalence of NAFLD in Chinese children was 6.3% (95%CI: 4.6% - 7.9%), and the prevalence of NAFLD in obese children was 40.4% (95%CI: 31.5% - 49.9%).Subgroup analysis showed that the prevalence of NAFLD was significantly different by gender, research areas and research time. Conclusions The prevalence of NAFLD among Chinese children and obesity children is relatively high.NAFLD in children is gradually becoming one of the major public health problems in China.

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non-alcoholic fatty liver disease / children / obesity / prevalence / Meta-analysis / China

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WANG Yu, YANG Zhi-ran, CHEN Run-hua. Meta-analysis of the prevalence of non-alcoholic fatty liver disease in Chinese children[J]. Chinese Journal of Child Health Care. 2022, 30(7): 764-769 https://doi.org/10.11852/zgetbjzz2021-1338

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