Research progress of exosomes in autism spectrum disorder

ZHU Yu-xuan; TIAN Ya-ning; PAN Jue; QIN Yan-nan

doi:10.11852/zgetbjzz2021-1269

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (12) : 1345-1349. DOI: 10.11852/zgetbjzz2021-1269

Review

Research progress of exosomes in autism spectrum disorder

ZHU Yu-xuan, TIAN Ya-ning, PAN Jue, QIN Yan-nan

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Abstract

Autism spectrum disorder(ASD) is a typical form of pervasive developmental disorder characterized by social interaction and communication disorders,attention deficits,narrow interests,and repetitive/stereotypical behavior patterns. In recent decades,the prevalence rate of autism has been on the rise all over the world and there is a lack of specific treatments. Therefore,it is very urgent to search for sensitive and specific biomarkers and specific treatments. Exosomes are nanoscale vesicles that can be released by most cell types in the central nervous system. Bioactive macromolecules such as RNA,proteins and lipids in exosomes participate in the material exchange and information exchange of various nerve cells, and play an important role in the regulation of nerve development, differentiation,regeneration and synaptic regulation. With the development of molecular biology and the improvement of diagnostic technology,exosomes have gradually become the focus of ASD research due to their advantages of convenient collection,stable structure,easy degradation of macromolecules in exosomes and the ability to pass the blood-brain barrier. It has been reported that exosomes are related to the occurrence and development of ASD,and may be an important source of diagnostic markers for ASD and a new drug treatment carrier. This article reviews the research progress of exosomes in ASD,in order to provide reference for early diagnosis,clinical treatment and prognosis judgment of ASD.

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exosome / autism / biomarkers

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ZHU Yu-xuan, TIAN Ya-ning, PAN Jue, QIN Yan-nan. Research progress of exosomes in autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2022, 30(12): 1345-1349 https://doi.org/10.11852/zgetbjzz2021-1269

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