Objective To analyze the related factors affecting the optimal score of Hammersmith Infant Neurological Examination (HINE) of 3- to 6-month-old infants, so as to provide basis for early intervention.Methods A total of 145 infants aged 3 to 6 months who received HINE evaluation in the Department of Developmental Behavior Pediatrics, the First Hospital of Jilin University from August 2019 to February 2021 were selected, including 70 infants in normal group and 75 infants in abnormal group. A total of 22 related factors that may affect the optimal score of HINE during pregnancy and perinatal period were investigated.Results The prevalence rates of intrauterine distress, amniotic fluid abnormality, birth asphyxia, intracranial hemorrhage and neonatal convulsion in abnormal group were significantly higher than those in normal group (χ2=6.24, 6.05, 5.51, 12.91, P<0.05). Multiple Logistic regression analysis showed that amniotic fluid abnormality(OR=3.38, 95%CI:1.38 - 8.29), intracranial hemorrhage(OR=4.09, 95%CI:1.59 - 10.49) and neonatal convulsion(OR=11.62, 95%CI:2.43 - 55.55) were independently risk factors for the optimal score of Hammersmith Infant Neurological Examination (HINE) (P＜0.05). Conclusion Early screening and intervention should be given to infants with amniotic fluid abnormality, intracranial hemorrhage and neonatal convulsion.
Key words
Hammersmith Infant Neurological Examination /
developmental level /
infants
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] Haataja L, Mercuri E,Regev R,et al. Optimality score for the neurologic examination of the infant at 12 and 18 months of age[J]. J Pediatr,1999,135(2):153-161.
[2] 唐久来,方玲玲,杨李,等.高危儿和特异性高危儿早期干预的进展[J].中华实用儿科临床杂志,2020,35(24):1841-1845.
[3] 唐久来,王宝田,李晓捷. 脑性瘫痪早期诊断和脑性瘫痪高风险儿诊断及早期干预进展[J]. 中华实用儿科临床杂志,2018, 33(15):1121-1125.
[4] Maitre NL,Chorna O,Romeo DM,et al. Implementation of the Hammersmith Infant Neurological Examination in a high-risk infant follow-up program[J]. Pediatr Neurol,2016,65:31-38.
[5] Romeo DM,Cioni M, Palermo F,et al. Neurological assessment in infants discharged from a neonatal intensive care unit[J]. Eur J Paediatr Neurol, 2013,17(2):192-198.
[6] Chatzioanidis I,Kyriakidou M,Exadaktylou S,et al. Neurological outcome at 6 and 12 months corrected age in hospitalised late preterm infants -a prospective study[J]. Eur J Paediatr Neurol,2018,22(4):602-609.
[7] Lata K, Jindal P, Verma A,et al. Comparison between trained specialist and medical student in performing neurological assessment of high-risk infant by Hammersmith infant neurological examination (HINE)[J]. Journal of Family Medicine and Primary Care,2020,9(12):6297-6298.
[8] 刘振寰,金炳旭,刘陈,等. 中文版Hammersmith婴儿神经学检查量表的信度和效度[J].中国儿童保健杂志,2020,28(3):273-276.
[9] Serenius F,Ewald U,Farooqi A,et al. Neurodevelopmental outcomes among extremely preterm infants 6.5 years after active perinatal care in Sweden[J]. JAMA Pediatr,2016,170(10):954.
[10] Azzopardi D,Strohm B, Marlow N,et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes[J]. N Engl J Med,2014,371(2):140-149.
[11] Haataja L,Cowan F,Mercuri E,et al. Application of a scorable neurologic examination in healthy term infants aged 3 to 8 months[J]. J Pediatr,2003,143(4):546-546.
[12] Novak I,Morgan C,Adde L,et al. Early,accurate diagnosis and early intervention in cerebral palsy: Advances in diagnosis and treatment[J]. JAMA Pediatrics,2017,171(9):897-907.
[13] Romeo DM,Ricci D,Brogna C,et al. Use of the Hammersmith Infant Neurological Examination in infants with cerebral palsy:A critical review of the literature[J]. Developmental Medicine & Child Neurology,2016,58(3):240-245.
[14] Haataja L, Mercuri E,Guzzetta A,et al. Neurologic examination in infants with hypoxic-ischemic encephalopathy at age 9 to 14 months: Use of optimality scores and correlation with magnetic resonance imaging findings[J].J Pediatr,2001,138(3):332-337.
[15] Romeo D,Guzzetta A,Scoto M,et al. Early neurologic assessment in preterm-infants: Integration of traditional neurologic examination and observation of general movements[J]. Eur J Paediatr Neurol,2008,12(3):183-189.
[16] 王耸,程洪斌,王晓东,等. 2100例脑性瘫痪患者的临床特征及产前危险因素分析[J]. 中华灾害救援医学,2018,6(1):24-29.
[17] 周雪,李欣欣,李可蒙,等.不安运动阶段影响婴儿全身运动质量的影响因素分析[J].中国儿童保健杂志,2019,27(4):436-439.
PDF(381 KB)
