Objective To evaluate the effect of the combination of nurturing care by medical, nursing, education and family parenting in promoting the development of preterm infants, so as to provide basis for the follow-up monitoring of high-risk preterm infants. Methods A retrospective analysis was conducted in 71 cases of high-risk premature infants followed up in Hubei Maternal and Child Health Hospital from January 2017 to June 2018.Infants followed up in early development clinic were selected into the study group, those followed up in general outpatient clinic were enrolled in the control group. Infants in the study group adopted medical-nursing-education-family parenting intervention, while children in the control group were given conventional guidance. Physical development and neuropsychological development levels of high-risk premature infants within 12 months of corrected age were dynamically monitored and compared between the two groups. Results The difference between the study group and the control group at 1 month of corrected age was only significant in body weight (t=4.709, P<0.05). At the corrected age of 3, 6 and 12 months, the body length, body weight, head circumference, mental development index (MDI) and psychological development index (PDI) of infants in the study group were significantly higher than those in the control group(P＜0.05). Time effects, within-group effects and interactions for length, weight, head circumference, MDI and PDI scores were statistically significant between the two groups (P< 0.05).Compared with the control group, the pass rate of 20 neuromotor development items at the corrected age of 3 and 6 months in the study group were significantly higher (χ²=4.064, 8.414, P<0.05), and increased more significantly with the increasing of age. Moreover, the prevalence rates of intellectual deficits and motor development delay at the corrected age of 12 months of infants in the study group were significantly lower than those in control group(χ²=4.769, 5.182, P＜0.05). Conclusion Medical-nursing-education-family parenting care can not only promote the early development of high-risk premature infants, but also reduce the occurrence of intelligent defects and motor development delay, which is helpful to repair brain injury and to improve the development level of high-risk premature infants to a certain extent.