Role of protein glycosylation in pediatric central nervous system disorders

REN Yu-qian; CHEN Jin-jin

doi:10.11852/zgetbjzz2021-0768

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (7) : 755-758. DOI: 10.11852/zgetbjzz2021-0768

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Role of protein glycosylation in pediatric central nervous system disorders

REN Yu-qian^*, CHEN Jin-jin

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Abstract

Protein glycosylation is an important post-translational modification, which plays an important role in the formation of protein function and structure.It is involved in many biological activities, such as cell adhesion, migration, intercellular communication, receptor activation, signal transduction and so on.In recent years, it has been found that a variety of glycosylation pathways are involved in the process of brain development.Abnormal glycosylation protein expression has a negative impact on brain development and participates in the occurrence and development of nervous system diseases.In this review, the effects of glycosylation modification of proteins on neural function and the central nervous system diseases in children caused by abnormal glycosylation are discussed, which provides a new perspective for finding new diagnostic biomarkers and therapeutic targets in pediatric central nervous system disorders.

Key words

glycosylated protein / brain development / pediatric central nervous system disorders

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REN Yu-qian, CHEN Jin-jin. Role of protein glycosylation in pediatric central nervous system disorders[J]. Chinese Journal of Child Health Care. 2022, 30(7): 755-758 https://doi.org/10.11852/zgetbjzz2021-0768

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