Association between maternal passive smoking exposure before/during pregnancy and the risk of autism spectrum disorders in offspring

LIU Xian; GUO Cheng; YI Peng; CHEN Yi-ru; CHEN Wen-xiong

doi:10.11852/zgetbjzz2021-0628

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (4) : 371-375. DOI: 10.11852/zgetbjzz2021-0628

Association between maternal passive smoking exposure before/during pregnancy and the risk of autism spectrum disorders in offspring

LIU Xian, GUO Cheng, YI Peng, CHEN Yi-ru, CHEN Wen-xiong

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Abstract

Objective To explore the association between maternal passive smoking exposure before/during pregnancy and the risk of autism spectrum disorders (ASD) in offspring, so as to provide theoretical reference for the prevention of ASD. Methods A total of 141 children diagnosed with ASD (ASD group) in Guangzhou Women and Children's Medical Center and a rehabilitation organization and 247 healthy children (control group) were enrolled in this case-control study. The questionnaire survey was performed to collect the general characteristics and parental passive smoking exposure information. Univariate and multivariate Logistic regression analysis were used to examine the association between perinatal maternal passive smoking exposure and the risk of ASD in their offspring. Results Maternal passive smoking exposure either before pregnancy (crude OR=6.69,95%CI:2.33 - 19.25) or during pregnancy(crude OR=5.78,95%CI:2.15 - 15.49) had significantly increased the risk of ASD in their offspring. After adjusting the confounders such as children's sex, parity, maternal education, maternal vitamin intake and paternal passive smoking before pregnancy, the trends above remained. After sex matching, the sensitivity analysis showed that maternal tobacco exposure before and during pregnancy still served as a risk factor for offspring's ASD. Conclusion Perinatal maternal passive smoking exposure might be associated with the increasing risk of offspring's ASD.

Key words

autism spectrum disorder / passive smoking / before pregnancy / during pregnancy / mother

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LIU Xian, GUO Cheng, YI Peng, CHEN Yi-ru, CHEN Wen-xiong. Association between maternal passive smoking exposure before/during pregnancy and the risk of autism spectrum disorders in offspring[J]. Chinese Journal of Child Health Care. 2022, 30(4): 371-375 https://doi.org/10.11852/zgetbjzz2021-0628

References

[1] Harris J. Leo Kanner and autism:A 75-year perspective[J]. Int Rev Psychiatr,2018,30(1):3-17.
[2] Maenner M, Shaw K, Bakian AV, et al. Prevalence and characteristics of autism spectrum disorder among children aged 8 years - autism and developmental disabilities monitoring network, 11 sites, United States, 2018[J]. MMWR Surveill Summ, 2021,70(11):1-16.
[3] Zhou H, Xu X, Yan W, et al. Prevalence of autism spectrum disorder in China: A nationwide multi-center population-based study among children aged 6 to 12 years[J]. Neurosci bull, 2020,36(9):961-971.
[4] Baxter A, Brugha T, Erskine H, et al. The epidemiology and global burden of autism spectrum disorders[J]. Psychol Med,2015,45(3):601-613.
[5] Jung Y, Lee A, McKee S, et al. Maternal smoking and autism spectrum disorder: Meta-analysis with population smoking metrics as moderators[J]. Sci Rep, 2017,7(1):4315.
[6] Roberts A, Liew Z, Lyall K, et al.Association of maternal exposure to childhood abuse with elevated risk for attention deficit hyperactivity disorder in offspring[J]. Am J Epidemiol, 2018,187(9):1896-1906.
[7] Zhang L, Hsia J, Tu X, et al.Exposure to secondhand tobacco smoke and interventions among pregnant women in China: A systematic review[J]. Preve Chronic Dis, 2015,12:E35.
[8] American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5)[M].Washington DC:American Psychiatric Publishing,2013.
[9] Zhang X, Lv C, Tian J, et al. Prenatal and perinatal risk factors for autism in China[J]. J Autism Dev Disord. 2010;40(11):1311-1121.
[10] 刘丹,詹建英,邵洁. 儿童孤独症谱系障碍的环境危险因素研究[J]. 中国当代儿科杂志, 2015,17(11):1147-1153.
[11] Larsson M, Weiss B, Janson S, et al. Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6-8 years of age[J]. Neurotoxicology, 2009,30(5):822-831.
[12] Tran P, Lehti V, Lampi K, et al. Smoking during pregnancy and risk of autism spectrum disorder in a Finnish National Birth Cohort[J]. Paediatr Perinat Ep, 2013,27(3):266-274.
[13] Kalkbrenner A, Braun J, Durkin M, et al.Maternal smoking during pregnancy and the prevalence of autism spectrum disorders, using data from the autism and developmental disabilities monitoring network[J]. Environ Health Persp, 2012,120(7):1042-1048.
[14] Kalkbrenner A, Meier S, Madley-Dowd P, et al. Familial confounding of the association between maternal smoking in pregnancy and autism spectrum disorder in offspring[J]. Autism Res, 2020,13(1):134-144.
[15] Caramaschi D, Taylor A, Richmond R, et al. Maternal smoking during pregnancy and autism: Using causal inference methods in a birth cohort study[J]. Transl Psychiat, 2018,8(1):262.
[16] Land T, Landau A, Manning S, et al. Who underreports smoking on birth records: A Monte Carlo predictive model with validation[J]. PLoS One, 2012,7(4):e34853.
[17] Semick S, Collado-Torres L, Markunas C, et al. Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome[J]. Mol Psychiatr, 2020,25(12):3267-3277.
[18] Sikdar S, Joehanes R, Joubert B, et al. Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking[J]. Epigenomics, 2019,11(13):1487-1500.
[19] Brannigan R, Healy C, Cannon M, et al. Prenatal tobacco exposure and psychiatric outcomes in adolescence: Is the effect mediated through birth weight?[J]. Acta Psychiat Scand, 2020,142(4):284-293.
[20] Browne H, Modabbernia A, Buxbaum J, et al. Prenatal Maternal Smoking and Increased Risk for Tourette Syndrome and Chronic Tic Disorders[J]. J Am Acad Child Psy, 2016,55(9):784-791.
[21] Gutvirtz G, Wainstock T, Landau D, et al. Maternal smoking during pregnancy and long-term neurological morbidity of the offspring[J]. Addict Behav, 2019,88:86-91.
[22] Indredavik M, Brubakk A, Romundstad P, et al. Prenatal smoking exposure and psychiatric symptoms in adolescence[J]. Acta Paediatr, 2007,96(3):377-382.
[23] Blte S, Girdler S, Marschik P. The contribution of environmental exposure to the etiology of autism spectrum disorder[J].Cell Mol Life Sci, 2019,76(7):1275-1297.
[24] Buck J, O'Neill H, Stitzel J. Developmental nicotine exposure engenders intergenerational downregulation and aberrant posttranslational modification of cardinal epigenetic factors in the frontal cortices, striata, and hippocampi of adolescent mice[J]. Epigenet Chromatin, 2020,13(1):13.
[25] 霍超,李晚晨,陶衡恒. 大学生自闭特质的现状调查及特征分析[J]. 社会科学前沿, 2020,9(1):13-20.